… It is strongly recommended to administer piperacillin–tazobactam as a prolonged (ie
continuous or extended) infusion to maximize target attainment [4]. A dose of 12/1.5 g/day is …

… pharmacokinetic analyses were … , piperacillin-tazobactam doses of ≥80/10 mg/kg given
every 8 h and infused over 4 h achieve adequate pharmacodynamic exposures in critically ill …

… Patients and methods: This pharmacokinetic study enrolled … study were therefore (i) to
investigate the pharmacokinetics … tazobactam is given in a fixed combination with piperacillin (ratio …

… of piperacillin and tazobactam PK CKRT literature. Given PK data in critically ill burn … unique
to our dataset is the addition of 2 critically ill burn patients treated with CVVH from the MHS (…

… administration to achieve appropriate pharmacodynamic targets. This review synthesizes
important pharmacokinetic elements for piperacillin-tazobactam in an … for critically ill patients …

… and solely been administered as a TDM-… for analysis. HPLC was performed to measure
PIP concentrations while the combination of PIP and tazobactam (PIP/TAZ) was administered to …

… of the University Hospital in Hradec Králove for multiple-trauma were given piperacillin/tazobactam
by 1-hour IV infusion 4/0.5 g every 8 h. PK variables: total and renal clearance (CLtot, …

… critically ill patients; thus, we hypothesized that extended infusion piperacillin-tazobactam
would improve piperacillin … commenced after administration of at least two doses of piperacillin-…

… , all simulated piperacillin and tazobactam … tazobactam (2.86 mg/L) was predicted to be
reached in 100% of the population when tazobactam in a dose of ≥ 2 g/ 24 h was administered …

… The aim of the current study was to elucidate the pharmacokinetics of the … Only quotients
of samples between the first and second piperacillin/tazobactam administration per study day …