… medications like codeine and meperidine (pethidine) have … While intrathecal morphine
provided sufficient pain relief, the … Derivatives of fentanyl used in humans include alfentanil, …

… Over time, anesthesiologists identified meperidine as an effective primary spinal anesthetic
… In addition, animal studies and human clinical studies have also shown that meperidine and …

… depression from opioids is greater in older people, the same … Although the potency of
intrathecal morphine-6-glucuronide … based on pharmacokinetics, but meperidine will accumulate …

… The purpose of this review is to describe the pharmacokinetic … with that of either morphine
or meperidine. First administered … with chronic intrathecal morphine infusion in humans. Anesth…

… data for methadone and morphine,30 meperidine,31 … and humans, good PD-PK relationships
in rats and humans have now … efficacy and CSF pharmacokinetics of intrathecal morphine-6…

… signaling by pain-modulating neurons to the spinal cord, and inhibits transmission from
primary … of morphine in human neonates and infants. The most controversial point related to …

… The rate of absorption of meperidine from the epidural space is … of morphine administered
via this route are available in humans… The main pharmacokinetic parameters of morphine are …

… intrathecal morphine dose is only 100 μg, thus intrathecal … in fat and it extensively binds
to human plasma proteins [29]. It is … for renal dysfunction with opioids like Meperidine. Most …

… in human cerebrospinal fluid (CSF) has followed intrathecal morphine injection in animals
and humans. … Intrathecal opioids reduce the release of gamma amino butyric acid (GABA) and …

… time on the pharmacokinetic parameters of midazolam did not … diurnal variation in midazolam
pharmacokinetics after intravenous … The pharmacokinetics of midazolam in man. Eur. J. …