… predicted and extremely variable using customary pharmacokinetic models. 14, 15 Goal peak
… , and Fentanyl Intrathecal opioids have been studied alone and in combination for the man…

… Pharmacokinetic considerations involve half-life of the parent … , morphine, and meperidine.The
natural opiates, particularly … other illicitly manufactured or sold opioids fuels the ongoing …

… ketamine 2 mg·kg −1 and midazolam 0.2 mg·kg −1 . Anesthesia was … to have a potential for
intrathecal use. In our previous … of human maternal and fetal pharmacokinetics of opioids and …

… other hypnotic drugs and opioids. PD interactions are the most clinically significant, and,
with other hypnotics, tend to be additive, whereas interactions with opioids tend to be highly …

… Morphine time-to-remedication data were taken from a study we previously conducted …
pharmacokinetics of morphine and its metabolites, morphine-3-glucuronide (M3G) and morphine-…

… Pharmacokinetic studies support an EC95 of 130 ng/ml clonidine in cerebrospinal fluid (CSF…
As a result, the dose response for neuraxial clonidine on arterial BP in humans is generally …

… treatments, opioid pharmacokinetics and pharmacodynamics, and … cesarean delivery patients
receiving intrathecal morphine [9]. … pathways of meperidine are hydrolysis by human liver …

… of the pharmacodynamics and pharmacokinetics of morphine, this … -pharmacodynamic
modeling of miotic effects in humans … morphine and midazolam effected ventilatory depression …

… was restricted to only human studies published in … Morphine is a substrate of the organic
cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics …