… many chemokines act as biased agonists of their receptors (13). The receptor CXC motif
chemokine receptor 3 (CXCR3… In addition, CXCR3 has small-molecule biased agonists, such as …

… Keywords: Cancer, Chemokine, CCR7, pharmacology The expression of CCR7 was …
In addition, we characterised OSC-19 as a suitable model to evaluate small molecule CCR7 …

… In this article, we summarize the current advances in the field of small molecule … chemokine
receptors and ligands (To date, nearly 50 chemokines and 20 signaling chemokine receptors …

… the chemokine receptors that is capable of recognizing small molecule scaffolds as agonists,
… VUF11418 and VUF10661 are dual agonists of CXCR3 and CXCR7, and therefore, by 264 …

… chemokine ligand 12). Importantly, CXCL11 and CXCL12 also bind to the chemokine
receptors CXCR3 … the addition of 5 nM of the small molecule agonist 1. Compounds from our …

… that regulates T cell function, and its endogenous chemokines CXCL9, CXCL10, and …
signaling exists at CXCR3. After identifying small molecule biased CXCR3 agonists using cell-…

… CXCR3 allosteric binding pocket of AMG 487 and RAMX3, two potent and selective
CXCR3 … Photoaffinity labeling is a common approach to elucidate binding modes of small-molecule …

… receptor is notable for the fact that it binds both the CXCR3 … , no small-molecule chemokine
receptor antagonists have been … Pharmacological characterization of the chemokine receptor, …

… 1), we can conclude that in general, small molecule ligands consist of aromatic … characterized
novel negative and positive allosteric modulators of the chemokine receptors CXCR3 …

… of small-molecule agonists of CXCR3 was largely neglected and only a few agonists
were … We combined this approach with detailed pharmacological characterization of novel …