… adenosine research, this review is designed to shed light on the pharmacological role of
adenosine … We describe the origin and metabolism of adenosine, and the classification, structure…

… Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues of …

… of adenosine receptors, to examine a multitude of receptor structures and novel ligands,
to gauge new pharmacology, and to evaluate clinical trials with adenosine receptor ligands. …

… pharmacological target for the treatment of neurodegenerative disorders, notably Parkinson’s
disease (PD). The selective A 2A receptor … the pharmacology of adenosine A 2A receptor …

… Among these, adenosine is the most relevant, acting through its adenosine A 2A receptor. …
agonists have been described in vitro at the receptor–receptor level or in more complex in vivo …

Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the
largest family of integral membrane proteins in the human genome, the G protein-coupled …

… , molecular and cellular pharmacology, and physiology of adenosine and the G-protein-coupled
receptors that it interacts with. These ARs, respectively named A1, A2A, A2B and A3, are …

… with dopamine D2 receptors, metabotropic glutamate type 5 receptors (mGlu5R) but also
with the cannabinoid CB1 receptor and with other adenosine receptors, such as A 1 receptor [[…

… the receptor in the conformation that is imposed by the ligand, and therefore the ligand
pharmacology will in effect be imprinted on the receptor. To identify stabilizing mutations, the …

… in vitro pharmacological profile of KW-6356 as an A 2A receptor … In addition, we determined
cocrystal structures of A 2A receptor … Pharmacological studies have shown that KW-6356 is a …