Deep learning in phosphoproteomics: methods and application in cancer drug discovery

N Varshney, AK Mishra - Proteomes, 2023 - mdpi.com
phosphoproteomics-based bioinformatics tools in cancer research in identifying novel drug
phosphoproteomics and the new cutting-edge deep-learning-based prediction methods. …

Integrating phosphoproteomics into kinase-targeted cancer therapies in precision medicine

X Wu, X Xing, D Dowlut, Y Zeng, J Liu, X Liu - Journal of proteomics, 2019 - Elsevier
… progresses in phosphoproteomics methodology and how phosphoproteomics profiling could
… , facilitate novel drug target discovery and overcome the therapeutic obstacles caused by …

Proteomic characterization of post-translational modifications in drug discovery

L Zhai, K Chen, B Hao, M Tan - Acta Pharmacologica Sinica, 2022 - nature.com
… quantitative proteomics and phosphoproteomics to study the dynamic changes in the
proteome and phosphoproteome in response to immunomodulatory drug treatment in clinical …

Investigation of cancer drug resistance mechanisms by phosphoproteomics

JC Boulos, MRY Idres, T Efferth - Pharmacological Research, 2020 - Elsevier
… and to discover novel drugs. This review highlights the role of phosphoproteomics in …
emerged as attractive tool for therapy monitoring and rationale drug discovery (Fig. 1) [[8], [9]…

Impact of phosphoproteomics in the translation of kinase‐targeted therapies

P Casado, M Hijazi, D Britton, PR Cutillas - Proteomics, 2017 - Wiley Online Library
… , LC-MS-based quantitative phosphoproteomics provides relevant information for the …
phosphoproteome profiling is being used in translational research as a means to identify drug

The emerging role of mass spectrometry-based proteomics in drug discovery

F Meissner, J Geddes-McAlister, M Mann… - … Drug Discovery, 2022 - nature.com
… most drugs; however, system-wide methods to monitor protein activity and function are still
underused in drug discovery… We discuss innovative strategies in early-stage drug discovery in …

Principles of phosphoproteomics and applications in cancer research

L Higgins, H Gerdes, PR Cutillas - Biochemical Journal, 2023 - portlandpress.com
… Thus, the study of the phosphoproteome stands to provide … and tools used in
phosphoproteomics and highlight how this … Challenges still exist in mass spectrometry …

Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics

CY Lee, M The, C Meng, FP Bayer… - Molecular Systems …, 2024 - embopress.org
… of the focus of the current study on the phosphoproteome. The screening deck contained all
71 approved KIs (at the time of writing) and 52 phase III drugs. These 123 KIs are particularly …

Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML

SJC Gosline, C Tognon, M Nestor, S Joshi, R Modak… - Clinical proteomics, 2022 - Springer
drug testing and genomic profiling of the Beat AML dataset with patient-derived proteomic
and phosphoproteomic … produce robust molecular biomarkers of drug response. Using a small …

Proteomics and phosphoproteomics in precision medicine: applications and challenges

G Giudice, E Petsalaki - Briefings in bioinformatics, 2019 - academic.oup.com
… molecular mechanism and discover personalized biomarkers, networks and treatments.
Here, we review examples of successful use of proteomics and phosphoproteomics data sets in …