… Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine
hydrolase activity. Chem Biol Interact 203, 217–220, doi:10.1016/j.cbi.2012.09.004 (2013). …

… of the cocaine metabolites and may even cause vasodilation, … design a cocaine
hydrolase (CocH), ie, a BChE mutant with a considerably improved catalytic activity against (−)-cocaine. …

… design and site-directed mutagenesis transformed human serum recombinant
butyrylcholinesterase (BChE) into a highly efficient cocaine … a plant-produced cocaine-hydrolase …

… cocaine, and its variants with improved cocaine hydrolase (… hydrolysis rate have also
been rational designed to reduce the … The rBChE expressed in plants and goat milk was also …

… enzyme of cocaine in human body is butyrylcholinesterase (BChE) … The first one of our
designed CocHs, known as CocH1 (… , the cocaine-hydrolyzing activity in the plant leaves gradually …

… following search terms: Cocaine, butyrylcholinesterase, hydrolase, and esterase. … Plants
as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity…

… endogenous butyrylcholinesterase which reduces cocaine to … continue to be made to
enhance the activity and the duration of … suggests that wide variations in hydrolases, expressed …

… but a physiological role for butyrylcholinesterase is just now emerging. … Rapid progress was
made in different laboratories … BChE versions that enhance the rate of cocaine inactivation by …

… study acetylcholinesterase and butyrylcholinesterase structure and … Rate-determining steps
can be made faster with residue … intensity and increasing binding activity of thioflavin-T with …

… Cocaine is a plant-based illicit drug commonly involved in … Human butyrylcholinesterase
(hBChE), the primary enzyme … the computational design of the Fc-fused cocaine hydrolases that …