… fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks bacterial cell wall
… to show oligomerization for different lipid II binders including the αβ-defensin copsin 31 and …

… Notably, lipid II is more than just a target molecule, since … The first defensin described as
binding lipid II is plectasin, … a model of the lipid II–plectasin complex, in which lipid II binds to a …

… of the Staphylococcus aureus cell membrane. We show that … for a Lipid II targeting antimicrobial
peptide is the defensin … Plectasin is a 40-amino acid fungal defensin produced by the …

… membrane bacterial targets such as Lipid II, outer membrane … Py4 and Lipid II based on that
of plectasin and Lipid II (Figure 1C,… of plectasin with Lipid II [24] also exists in the Py4-Lipid II …

… CSαβ defensins specifically target lipid II.16 These CSαβ … of the lipid II GlcNAc sugar on the
binding affinity of plectasin16 … in certain regions of the cell membrane.5b, 6b We can envision …

… to demonstrate that the cell wall precursor plays a decisive … a lipid II-binding motif with many
others defensins from fungi … lipid II has reduced affinity for plectasin and related defensins…

… defensins and the recently discovered teixobactin. By hitting … indicate that plectasin has a
higher affinity for lipid II than lipid I… the bacterial cell, including the cell wall precursor lipid II and …

… that target Lipid II such as the lantibiotic nisin and defensins. We … and dislocating Lipid II
leads to dysfunction of the cell wall … In this study, interactions between plectasin and the solvent-…

… target for AMPs is the peptidoglycan precursor, Lipid II, which is … of the cell wall biosynthesis
in Gram-positive bacteria. Aside … defensins, targeting of Lipid II is best illustrated by plectasin …

… to the bacterial cell wall precursor lipid II and inhibiting the cell wall … Plectasin, the first fungal
CSαβ DLP, showed strong … cellular targets, the DNA-binding properties of P2 or plectasin …