Cell-Autonomous Endocannabinoid Production Shapes Polarized and Dynamic Distribution and Signaling Patterns of Cannabinoid CB1 Receptors in Neurons

D Ladarre, Z Lenkei - Endocannabinoids and Lipid Mediators in Brain …, 2017 - Springer
… as key dynamic component of cellular function through the control of … This polarization is
established by specific targeting … both mechanisms is hard to detect but recent studies tend to …

The immunosuppressive effect of the endocannabinoid system on the inflammatory phenotypes of macrophages and mesenchymal stromal cells: a comparative study

T Ruhl, C Corsten, JP Beier, BS Kim - Pharmacological Reports, 2021 - Springer
… Succesful polarization was detected by secreted soluble … and exhibited a typical
spindle-shaped morphology (Fig. 1a). … , but no cannabinoid compound affected the production of …

Characterisation and localisation of the endocannabinoid system components in the adult human testis

JE Nielsen, AD Rolland, E Rajpert-De Meyts… - Scientific reports, 2019 - nature.com
… The cannabinoid receptors, CNR1 and CNR2 were detected at … the protein expression
pattern of the endocannabinoid-… of the MGLL staining was somewhat polarised, weakest near …

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

A Fletcher-Jones, KL Hildick, AJ Evans, Y Nakamura… - Elife, 2019 - elifesciences.org
… to make the receptors available to bind endocannabinoids. … somatodendritic compartment
and is not detected in the proximal 50 µm of … axonally polarised, the degree of polarisation was …

Protein interactors and trafficking pathways that regulate the cannabinoid type 1 receptor (CB1R)

A Fletcher-Jones, KL Hildick, AJ Evans… - Frontiers in molecular …, 2020 - frontiersin.org
Endocannabinoid system signaling downstream of CB1R is … This review focuses on the
trafficking and polarized surface … the ER, intracellular CB1R is detected in the axon as soon as 25 …

Cannabinoid and planar cell polarity signaling converges to direct placentation

YS Kim, Y Li, J Yuan, JP Borg… - Proceedings of the …, 2021 - National Acad Sciences
endocannabinoids via G protein–coupled cannabinoid … The PCP pathway is best known
for its role in cell polarization at the … to CRE expression patterns, CRE activity was detected in …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
… trial did not detect a beneficial effect of oral Δ 9 -THC in … often unpredictable and bell-shaped
dose-response curves … 9 -THC are complex and involve many cellular and molecular …

[HTML][HTML] The endocannabinoid system in the visual process

SJ Pasquaré, E Chamorro-Aguirre… - Journal of Photochemistry …, 2023 - Elsevier
… (cAMP) production is a characteristic response of cannabinoid … In mice retina, DAGLα was
detected in OFF bipolar cells type 1 … This figure shows how cannabinoid-related enzymes and …

Cannabinoid receptors modulate neuronal morphology and AnkyrinG density at the axon initial segment

M Tapia, A Dominguez, W Zhang… - Frontiers in Cellular …, 2017 - frontiersin.org
… Neuronal polarization underlies the ability of neurons to integrate and transmit information.
… was detected in dendrites or in the AIS (Figure 1C). Based on this specific pattern of …

[HTML][HTML] Cannabinoids regulate sensory processing in early olfactory and visual neural circuits

T Heinbockel, A Straiker - Frontiers in neural circuits, 2021 - frontiersin.org
… , the endogenous cannabinoids or endocannabinoids, also … The authors found a THC effect
on both olfactory detection thresholds and … polarization, subsequent changes in calcium and …