Inhibitors of the PLK1 polo-box domain: drug design strategies and therapeutic opportunities in cancer
… , PLKs contain a unique C terminal structure involved in Ser-pSer/pThr binding, called the
Polo box domain (PBD), comprising one or two polo boxes … Their PBDs contain two polo boxes …
Polo box domain (PBD), comprising one or two polo boxes … Their PBDs contain two polo boxes …
[PDF][PDF] MECHANISMS OF POLYPOSIS IN PEUTZ-JEGHERS SYNDROME MODELS
ED Moreno - helda.helsinki.fi
… This thesis project aims to contribute a modest yet significant piece to the ever-evolving …
relative position within the crypt. Stem cells at the bottom (at 0 and +1 position relative to the crypt …
relative position within the crypt. Stem cells at the bottom (at 0 and +1 position relative to the crypt …
The Role of Polo-like Kinase 1 (PLK1) in Mammalian Meiotic Centrosome Duplication and Separation
Y Zhang - 2019 - jscholarship.library.jhu.edu
… and a C-terminal structure called the polo box domain (PBD) that is … view of the most frequently
studied aspects of PLK functions. … Polo Boxes Come out of the Crypt: A New View of PLK …
studied aspects of PLK functions. … Polo Boxes Come out of the Crypt: A New View of PLK …
Targeting Polo-Like Kinase 1 in Pediatric Leukemia
O Goroshchuk - 2020 - search.proquest.com
… the first to describe and implement a concept of a stem cell as a … a polo-box domain (PBD)
which is a unique feature of the Plk … that our bodies developed evolutionary to silence the alien …
which is a unique feature of the Plk … that our bodies developed evolutionary to silence the alien …
The role of polo-like kinase 4 (PLK4) in chromosome segregation and genome maintenance in mammalian meiosis
M Jamabo - 2016 - jscholarship.library.jhu.edu
… 9 FIGURE 7: PLK functions and localizations in mammalian … In contrast, the PLK4 polo
box and its crypto polo box do not … motif, which is conserved all through evolution (Figure 8). …
box and its crypto polo box do not … motif, which is conserved all through evolution (Figure 8). …
PLK4: a promising target for cancer therapy
Y Zhao, X Wang - Journal of cancer research and clinical oncology, 2019 - Springer
… The Polo-like kinases (PLKs) are a family of serine/threonine kinases that play a critical
role … region contains a single Polo-box and a central domain called the “cryptic Polo-box” (CPB). …
role … region contains a single Polo-box and a central domain called the “cryptic Polo-box” (CPB). …
Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified …
Y Sun, Y Xue, P Sun, S Mu, H Liu, Y Sun… - Journal of Medicinal …, 2023 - ACS Publications
… (3−5) PLK4, one of the five members of PLKs, also known as … the kinase activity, a “polo-box
(PB)” domain necessary for … ), a rapidly emerging strategy, has evolved as a novel chemical …
(PB)” domain necessary for … ), a rapidly emerging strategy, has evolved as a novel chemical …
Revisiting centrioles in nematodes—historic findings and current topics
A Schwarz, P Sankaralingam, KF O'Connell… - Cells, 2018 - mdpi.com
… question of how the centrosome evolved and took its shape was, … thought to lack the cryptic
polo box (CPB) and polo box 3 (PB3) … Thus, while ZYG-1/Plk-4 is recruited in all three species …
polo box (CPB) and polo box 3 (PB3) … Thus, while ZYG-1/Plk-4 is recruited in all three species …
Therapeutic potential of targeting polo-like kinase 4
Q Lei, Q Yu, N Yang, Z Xiao, C Song, R Zhang… - European Journal of …, 2024 - Elsevier
… Kinase domains are shown in orange, the polo-box domains in … perspective of PLK4 as a
molecular target for cancer therapy. … PLKs originate from their family ancestral member, the polo/…
molecular target for cancer therapy. … PLKs originate from their family ancestral member, the polo/…
[PDF][PDF] Elucidating the role of centrosomal proteins during meiotic DNA repair
ML Reategui Via y Rada - 2018 - jscholarship.library.jhu.edu
… Given that the reductional meiotic program has evolved to … The discovery of polo-like
kinases (PLKs) followed shortly. … PBDs are a tandem set of ~100 amino acid polo boxes …
kinases (PLKs) followed shortly. … PBDs are a tandem set of ~100 amino acid polo boxes …