… me to take up the position in biobank when my … PLKs, the PBD contains two polo boxes
which are required for regulating its kinase activity, except PLK4 that contains only one polo box …

… Protein structure of each Plk is aligned using the kinase domain (yellow box). Poloboxes
are shown in blue, and the polo-box binding domain is represented as a red, as indicated. …

… It was always great to go out to lunch, have a coffee or just hang out in the office. Than2s for
… it was originally thought to contain a single polo box, however it has been found to … Page 47 …

… ACD strategies employed throughout evolution and among … Polo kinase plays a crucial role
in centrosome asymmetry. … stem cell niche at the base of the crypt. Putative quiescent stem or …

… M-phase kinases are polo-like kinases (Plks) and Aurora … half, the polo box domain (PBD),
which comprises two polo box … This family has been highly conserved during evolution. There …

… one group out of the most evolutionary conserved transport … full thickness small intestinal
crypt-villus or colonic crypt-surface cell … allows a closer look at the activity and function of certain …

… with commensal bacteria (see Box 1 for Glossary), enhance … at different locations in the crypt:
crypt base columnar (CBC) stem … Moreover, the evolutionary conservation of regenerative …

… Right panels are enlargements of the yellow boxes. Scale … Indeed, we found that colonic
crypt ISCs purified from DSS-treated St6 … The evolution of 20 human STs that form specific sugar …

… This thesis project aims to contribute a modest yet significant piece to the ever-evolving …
relative position within the crypt. Stem cells at the bottom (at 0 and +1 position relative to the crypt …

… , it is rather an organism evolving over time, and possessing features and aptitudes that are
… image-generating faculty whose non-resolution in turn provokes the fantasia to new image …