… ), augment the generation of immune complexes. However, there is … B cells leads us to
hypothesize that they may play a key role in driving chronic inflammation in systemic autoimmunity…

… human SLE, including polyclonal B cell proliferation, antinuclear antibody production and the
development of immune-complex-… by nucleic acid-containing immune complexes has been …

… be regulated to prevent autoimmunity. Cognate T … polyclonal IgM produced after 7 d forms
a complex, with the excess anti-μ resulting in IgG1-IgM ICs in the supernatant. These B cell …

… multiple immunological diseases including autoimmune and … either through inflammatory
immune complexes or in situ … now permit us to address these issues at the single cell level, …

… DNA-containing immune complexes induced IL-2 production by these B cells in a TLR9-dependent
manner. Interestingly, simultaneous exposure to TLR9 ligands and anti-IgM led to …

… only associated with increased polyclonal B cell activity, but also … with B cell activation and
immune complex formation which … from complement fixation by immune complexes, and the …

… The non-selective activation of polyclonal B cells with a … RF B cells in patients with systemic
autoimmune diseases … RF B cell activation by immune complexes is accompanied by the …

… B cells, and human self-reactive V H 4-34-expressing B cells. Herein, we summarize the
functions of recently described B cell … in both animal models and humans. We also highlight the …

… prevented their hyperactivation and ensuing autoimmunity. … of autoantibodies and deposition
of immune complexes in the kidney (… We believe these studies move us closer to precision …

… IgG-NAA are regulated to prevent autoimmune disease. The Fc … cord B cells and 15–20% of
circulating adult B cells, and is … above findings with human leukocytes, led us to investigate if …