[HTML][HTML] Morphometrical, morphological, and immunocytochemical characterization of a tool for cytotoxicity research: 3D cultures of breast cell lines grown in ultra-low …

F Malhão, AC Macedo, AA Ramos, E Rocha - Toxics, 2022 - mdpi.com
… After the primary antibody incubation and after each step of the detection system, slides …
We selected a panel of antibodies targeting different outputs for the MCAs’ ICC characterization. …

Generation and validation of monoclonal antibodies against the maltose binding protein

YN Park, RA Glover, KJ Daniels… - Monoclonal Antibodies in …, 2016 - liebertpub.com
… MBP precipitates on the western blot were detected with rabbit polyclonal anti-MBP
antibody (Thermo Fisher Scientific). The Odyssey dye IR Dye 800-conjugated goat anti-rabbit …

[HTML][HTML] Bortezomib in Combination with Physachenolide C Reduces the Tumorigenic Properties of KRASmut/P53mut Lung Cancer Cells by Inhibiting c-FLIP

T Kanagasabai, Z Dunbar, SG Ochoa, T Farris… - Cancers, 2024 - mdpi.com
… , and the maximal c-FLIP expression was detected in castrate-… Cancer cells are often exposed
to a metabolically challengingstudy was to maximize the anticancer potential by using low

Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

Y Liu, J Peng, T Sun, N Li, L Zhang… - … of Sciences, 2017 - National Acad Sciences
… We challenged wild-type and EZH2-deficient mice with 3% … higher relative abundance of
c-FLIP mRNA in EZH2 IEC−/− … low levels of c-FLIP, thereby making cells prone to apoptosis. …

[HTML][HTML] Regulatory role of sphingosine-1-phosphate and C16: 0 ceramide, in immunogenic cell death of colon cancer cells induced by Bak/Bax-activation

JA Hengst, AJ Nduwumwami, JK Yun - Cancers, 2022 - mdpi.com
… However, recent studies have challenged this assertion by … , low dose ABT/AZD had minimal
effect on levels c-FLIP and … Furthermore, we did not detect the formation of dimeric CRT …

[HTML][HTML] Nanoparticles: The future of effective diagnosis and treatment of colorectal cancer?

R Naeimi, R Najafi, P Molaei, R Amini… - European journal of …, 2022 - Elsevier
… Colorectal cancer (CRC) is one of the most challenging malignancies in terms of diagnosis
… include low absorption and solubility as well as metabolic problems; several studies have …

Small-molecule natural product physachenolide C potentiates immunotherapy efficacy by targeting BET proteins

P Tewary, AD Brooks, YM Xu, EMK Wijeratne… - Cancer research, 2021 - AACR
… the TNF family or agonist antibodies to their death receptors … Elevated levels of cFLIP
are often associated with poor … a grant from the Arizona Biomedical Research Center (grant …

Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

AA Farooqi, M De La Roche, MBA Djamgoz… - Seminars in cancer …, 2019 - Elsevier
… expression is associated with poor prognosis in metastatic colon … an overarching goal
of biomedical researchers. TNF-related … -triggered c-FLIP depletion was independent of c-FLIP

[HTML][HTML] The genetic and molecular basis for canine models of human leukemia and lymphoma

AC Avery - Frontiers in Oncology, 2020 - frontiersin.org
… The expression of downstream anti-apoptotic genes (BCL2, c-FLIP… at low levels in only one
study: TNFAIP3 (14% of 14 cases) and … A greater challenge will be creating more focused …

[HTML][HTML] Combination Therapies Targeting Apoptosis in Paediatric AML: Understanding the Molecular Mechanisms of AML Treatments Using Phosphoproteomics

AA Ali, LV Cairns, KM Clarke, JK Blayney… - … of Molecular Sciences, 2023 - mdpi.com
… are no antibodies available to detect phosphorylated VDAC-1… analysis showed both
upregulation of TRAF6 and c-FLIP, … overexpression is linked to poor prognoses and chemotherapy …