A proteomic study of myeloproliferative neoplasms using reverse-phase protein arrays
R Tognon, DC Almeida-e-Silva… - Leukemia & …, 2020 - Taylor & Francis
… available to tackle this challenge, including mass cytometry, … our group showed a deregulation
in C-FLIP in which leads to … Despite shortcomings in the detection of certain proteins and …
in C-FLIP in which leads to … Despite shortcomings in the detection of certain proteins and …
4th Symposium on Advances in Cancer Immunology and Immunotherapy, November 29–December 1, 2018, Athens, Greece
… Collectively, these data suggest a critical role of c-FLIP in … the poor clinical outcome of this
study was due to the low number of … Immunocapture offers an opportunity for identification of …
study was due to the low number of … Immunocapture offers an opportunity for identification of …
Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells
… with DDLPS have a poor prognosis after surgical resection of … the most challenging cancers
to treat, and further studies are … -PE conjugated antibodies for 1 h at 4 C for determination of …
to treat, and further studies are … -PE conjugated antibodies for 1 h at 4 C for determination of …
Extracellular vesicle delivery of TRAIL eradicates resistant tumor growth in combination with CDK inhibition by dinaciclib
C Ke, H Hou, J Li, K Su, C Huang, Y Lin, Z Lu, Z Du… - Cancers, 2020 - mdpi.com
… However, it is very challenging to find positive predictors of … In our study mice were treated
by low doses of dinaciclib and … decreases of anti-apoptotic proteins c-FLIP, Mcl-1 and Bcl-2 …
by low doses of dinaciclib and … decreases of anti-apoptotic proteins c-FLIP, Mcl-1 and Bcl-2 …
RIP1–HAT1–SIRT complex identification and targeting in treatment and prevention of cancer
V Carafa, A Nebbioso, F Cuomo, D Rotili… - … Cancer Research, 2018 - AACR
… with low toxicity during follow-up phases and in cases of … with anti–acetyl-lysine antibody,
we observed the presence … of IAP and FLICE-inhibitory protein (c-FLIP). Interestingly, IAP …
we observed the presence … of IAP and FLICE-inhibitory protein (c-FLIP). Interestingly, IAP …
Over fifty years of life, death, and cannibalism: a historical recollection of apoptosis and autophagy
… Research in biomedical sciences has changed dramatically … Moreover, sensitizer proapoptotic
Bcl-2 proteins, such as Bad, … 2000, morphological analysis was the only way to detect …
Bcl-2 proteins, such as Bad, … 2000, morphological analysis was the only way to detect …
Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma
… suffice, we started with cells in a “low Myc” state and, at the time … of Myc, there are reports
challenging the notion that there is a … via overexpression of CFLAR/c-FLIP or by CRISPR/Cas9 …
challenging the notion that there is a … via overexpression of CFLAR/c-FLIP or by CRISPR/Cas9 …
PDE5 inhibitors offer novel mechanisms in combination and solo cancer therapy
RW Lyday, AM Etters, C Kim, F Magana… - Current Cancer …, 2017 - ingentaconnect.com
… structure of zaprinast, a weak phosphodiesterase inhibitor, and … Brain tumor treatment poses
challenges in delivery due the … the cellular FLICE inhibitory protein (c-FLIP). Blood 2006; 107…
challenges in delivery due the … the cellular FLICE inhibitory protein (c-FLIP). Blood 2006; 107…
Realizing the clinical potential of immunogenic cell death in cancer chemotherapy and radiotherapy
BL Rapoport, R Anderson - International journal of molecular sciences, 2019 - mdpi.com
… of subsequent experimental studies, clearly challenged existing … In this context, DISC is
regulated by the inhibitor, c-FLIP (… with a poor prognosis [79]. On the other hand, Aoto et al., in a …
regulated by the inhibitor, c-FLIP (… with a poor prognosis [79]. On the other hand, Aoto et al., in a …
[HTML][HTML] Engineered nanoparticles as emerging gene/drug delivery systems targeting the nuclear factor-κB protein and related signaling pathways in cancer
R Eskandani, M Kazempour, R Farahzadi… - Biomedicine & …, 2022 - Elsevier
… antibodies (Abs)) have been demonstrated to inhibit the NF-κB pathway. Low stability in the
circulation system, weak … of p65 and a low level of IκBα expression were detected in prostate …
circulation system, weak … of p65 and a low level of IκBα expression were detected in prostate …