… to engulf it through fimbriae, thereby activating cross-talk signaling from TLR2 to the beta2
integrin … Modulating the activation of TLR2 may represent a promising approach to eliminate …

… , required for fimbria promotion and expression remain unknown. … gingivalis and enable it
to bind host cells. FimA … in human monocytes and murine peritoneal macrophages [45,121]. A …

… -mediated interactions with Toll-like receptor 2 (TLR2) and the β2 integrin … fimbriae may
be actively binding to receptors on the macrophage surface, facilitating greater internalization …

… , largely because of its ability to modulate the entire ecosystem by … gingivalis LPS can promote
the internalization of VE-cadherin … of LDL by macrophages to form foam cells (187), with P. …

… Given the prior evidence for the role of P, gingivalis fimbriae … polymorphism in modulating
immune-modulatory activity by … diminished NF-κB activity in the macrophage via a reduction …

… Interestingly, P2X7 receptor distribution in macrophages may be modulated by P. … beta2
integrin adhesive activity and promote binding to and internalization by macrophages,” Infection …

… vitro growth culture can modulate TLR4/2 activation and E-selectin expression by P. …
gingivalis in macrophages through the hijacking of the TLR2 signalling pathway and internalisation …

… of mechanisms be rapidly internalized, thus OMVs would … ) macrophages were primed
with Porphyromonas gingivalis … is critical to understanding and modulating the progression of …

… : in Porphyromonas gingivalis infection (both in vitro and in vivo), it promotes bacterial …
equi can be in internalized by murine macrophages in the absence of TLR2, CR3, or FcγRIII …

… domain differentially modulated TNF-α … Porphyromonas gingivalis fimbriae activates a
TLR2-dependent signalling pathway promoting binding to and internalization by macrophages …