… Based on these findings, various trans-resveratrol and trans-stilbene derivatives have
become appealing targets for drug design as potential selective COX-2 inhibitors. The most …

… , integrin has a well-established role in cancer cell signal transduction pathways where
antagonism of integrin activity is a potentially useful strategy of cancer treatment [Citation33]. …

… claimed lower potential of serious … treatment of corticosteroids, while the other (ie, COX-2)
is induced by the inflammatory stimuli or cytokines that can be inhibited by the administration of …

… potential to greatly increase the effectiveness of chemotherapy. Our extensive understanding
of selective COX-2 inhibitor … the widespread administration of selective COX-2 inhibitors as …

… In this article, we review the preclinical and clinical evidences supporting the role of COX-2 …
potential therapeutic use of COX-2 inhibitors as (1) anticonvulsants for epilepsy management …

… could be a suitable choice as adjuvants in the therapeutic management of … COX-2 inhibitors’
efficacy used alone or as part of combination therapy in melanoma. COX-2 inhibitors tested …

… cancer has been already observed [95,96], along with the potential clinical benefit of a selective
COX-2 inhibitor … combination treatment with COX-1- and COX-2-selective inhibitors more …

… In addition, such a combination can reduce toxicity and chemoresistance and enhance
radiosensitivity, although COX-2 inhibitors-related cardiotoxicity may potentially affect its use. …

… of potential new therapeutic indications for COX-2 inhibitors conclude this review. … breast
cancer [202, 208, 211]. Nimesulide is used in the treatment of breast cancer [212] where COX-2 …

… towards COX-2 inhibition compared to indomethacin. Compounds 3d, 3g and 6a exhibited
significantly increased potency towards COX-2 … Furthermore, the selective COX-2 inhibitor 3g …