… other molecules, including mitochondrial DNA (mtDNA), RNA, … Cisplatin binding to mtDNA
further creates adducts that are … ovarian cancer cell, preferentially cisplatin-resistant cells. Our …

… with cisplatin [22], as cisplatin binds to the copper binding motif … cisplatin could preferentially
target mitochondrial DNA … repair of DNA cross-links in chinese hamster ovary cells treated …

… of mitochondrial respiration in cisplatin sensitivity, we have … wild-type and mitochondrial
DNA depleted Rho0 yeast cells. … binds mitochondrial DNA more efficiently than nuclear DNA (9…

… Cisplatin binds mtDNA with higher efficiency than to nuclear … mainly at the N-7 of guanine
29 and preferentially forms DNA adducts at runs of consecutive guanine nucleotides (poly-G; …

… localization, mitochondrial DNA differs from nuclear DNA in … Later studies sought to evaluate
whether cisplatin preferentially … the cellular sensitivity of Chinese hamster ovary cells both …

… cells. These findings indicate that newly identified mutations in mitochondrial DNA may lead
to acquired cisplatin … This suggests that the binding of CDDP to mtDNA may cause mtDNA …

… of cellular pharmacokinetics. We found that cisplatin predominantly accumulated in
mitochondria of renal tubular epithelial cells, and the amount of binding with mitochondrial DNA (…

… in mitochondrial DNA (mtDNA), because mitochondria are not … preferentially engulf and
outcompete neighboring cells with … and Chinese hamster ovary cells. TREK-1 overexpression …

… carcinoma and Chinese hamster ovarian cells significantly … heteroplasmy SNPs across the
entire mitochondrial genome. … showed that J cybrids preferentially use glycolysis and have …

… complementing defective repair in Chinese hamster cells) XRCC5, … mitochondrial protein
with vital and lethal functions. Cisplatin binds to mitochondrial DNA as well leading to cell …