A liver biopsy validation pilot study of shear wave elastography, APRI, FIB-4, and novel serum biomarkers for liver fibrosis staging in children with chronic viral …

R Mercedes, J Brown, C Minard, CM Tsai… - Global Pediatric …, 2020 - journals.sagepub.com
… with biliary atresia, nonalcoholic fatty liver disease, cystic fibrosis–associated liver disease,
and adults with chronic viral hepatitis show promise for accurately staging liver fibrosis. It is …

[HTML][HTML] IL-20 in acute kidney injury: role in pathogenesis and potential as a therapeutic target

TY Lin, YH Hsu - International journal of molecular sciences, 2020 - mdpi.com
… metabolic waste products and toxic substances as well as … in the kidney are decreased in
MCP-1-deficient mice. MCP-1 … Oxidative stress plays an essential role in the pathogenesis …

Non Alcoholic Fatty Liver Disease: non invasive markers of severity and new experimental treatments

P Pesce - 2018 - research.unipd.it
… directly cause toxicity by increasing oxidative stress and by … results, showing that MCP-1-deficient
mice do not exhibit reduced … the new therapies and prevention programs for hepatitis C …

Mechanisms behind the atherothrombotic effects of acrolein, a review

MR Zirak, S Mehri, A Karimani, M Zeinali… - Food and Chemical …, 2019 - Elsevier
… Investigations during the last decades have shown that acrolein via various mechanisms
such as oxidative stress, enhancement of inflammatory processes and the activation of matrix …

[HTML][HTML] Liver X receptors regulate hepatic F4/80+ CD11b+ Kupffer cells/macrophages and innate immune responses in mice

K Endo-Umeda, H Nakashima, S Komine-Aizawa… - Scientific reports, 2018 - nature.com
… -KO mice, and measured inflammation and liver injury markers in … are necessary for protection
from acute liver inflammation. … intestinal bacterial translocation or LPS toxicity. LXRα/β-KO …

Role of chemokines, innate and adaptive immunity

KA Zimmerman, K Hopp, M Mrug - Cellular signalling, 2020 - Elsevier
… However, MCP-1 deficiency substantially increased the survival of cpk mice by preventing the
… of MCP-1 deficient mice to recruit infiltrating macrophages to the site of kidney injury is due …

Monocyte chemoattractant protein-1, interleukin-1 beta, and Neutrophil gelatinase associated Lipocalin are upregulated in patients with diabetic nephropathy.

HJAL HASSANI, WS HAMEED… - International …, 2020 - search.ebscohost.com
… ) with subsequent generation of oxidative stress via activation of … The initial studies of
MCP-1-deficient diabetic kidneys … in c-related endstage liver disease. (20150 Gastroenterology …

[HTML][HTML] Liver X receptors regulate cholesterol metabolism and immunity in hepatic nonparenchymal cells

K Endo-Umeda, M Makishima - International Journal of Molecular …, 2019 - mdpi.com
… and protectionmice fed HFCD for four weeks, associated with hepatic cholesterol
accumulation [87] (Figure 2). LPS challenge in these mice induces more severe hepatic damage. …

[HTML][HTML] … monophosphate–activated protein kinase—Vacuolar adenosine triphosphatase–pH axis: A key regulator of the profibrogenic phenotype of human hepatic …

G Marrone, F De Chiara, K Böttcher, A Levi, D Dhar… - Hepatology, 2018 - journals.lww.com
… Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated … Chronic
liver disease mediated by activation of hepatic stellate cells (HSCs) and Kupffer cells (KCs) …

Endothelial dysfunction in obesity

A Engin - Obesity and lipotoxicity, 2017 - Springer
… arteries is associated with oxidative stress , activation of the … When the genetically C
receptor-deficient and MCP-1 -deficient … Hence, PP2A inhibitors not only prevent disruption of the …