… to a rewarding dose of cocaine (10 mg/kg) elevating the … induced cocaine seeking in rats
after extended withdrawal from … If this holds true, our findings are in agreement with a previous …

… of place conditioning to measure drug-reward associations dates back to at least 1957, to a
study using morphine on rats in a Y-maze 3,4 . Over the past … -tests, increases in the cocaine-…

… to attribute incentive salience to reward cues (sign-trackers [STs] … before testing for drug-induced
reinstatement of cocaine … , or how readily demand decreases as price increases; (4) an …

… Animals underwent consecutive daily rGT and cocaine self-administration sessions, such …
extinguished, but levers would remain extended and responses monitored. Responses on the …

… press for a maximum of 30 infusions or for a 3 h time limit. For the final 6 d, the dosage of …
cocaine-exposed (gray) rats for each day of self-administration. Data points represent each day. …

… DA signalling prior to drug exposure affects either reward-… , is targeting dopaminergic neurons
and increases extracellular … for cocaine, though the exposure sessions were extended to …

… or an increased threshold for the devaluation of cocaine. … non-contingent cocaine infusions
immediately before LiCl … This testing paradigm was adapted from food reward devaluation …

… rats prior to exposing them to cocaine using conditioned place … the ratio of effort to reward to
measure cocaine-seeking, we … The observed increases in pre-synaptic sensitivity to cocaine …

… , 60 min before the start of the next dark phase (1600). Three … parallel increases in cocaine
intake over the 14-day period (… of an abstaining partner will limit overall cocaine intake, thus …

… 1-h access to cocaine self-administration before receiving non-… reward in mice; whereas,
Homer2b knockdown reduces … receptor) fail to form conditioned place preference and locomotor …