… to Alzheimer’s Disease and certain malignancies, respectively. Several known molecules
involved in APP processing, including its regulation … between cancer and Alzheimer Disease. …

… processing of the amyloid precursor protein (APP) by membrane-bound proteases, namely
the β-… Membrane trafficking plays a key role in the regulation of APP processing as both APP …

… Aβ is derived from amyloid precursor protein (APP) via intracellular proteolytic processing. …
(A) Schematic diagram of amyloid precursor protein (APP) depicting the endocytosis motif and …

… processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the
Alzheimer’s disease (… function and bioenergetics modify APP processing and Aβ production. …

… (AD) is a common neurodegenerative disease whose … of amyloid precursor protein (APP),
a single transmembrane aspartic protein that is cleaved by β- and γ-secretases to produce β-…

… Aβ peptides are derived from amyloid precursor protein (APP) via the sequential cleavage
by β- … At this point, it is vital to understand the regulation of both old and new players in APP …

… composed of hyperphosphorylated tau protein. Aβ is generated by proteolytic processing
of the β-amyloid precursor protein (APP). Most individuals with Down syndrome (DS) have …

… eg reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident
… processing of amyloid‐β precursor protein ( APP ) leading to the accumulation of amyloid‐β …

… regulate miRNA expression as chromatin immunoprecipitation studies demonstrated that it
binds to the regulatory … ma-secretase processing of beta-amyloid precursor protein at a site …

… We also find that APP protein level does not influence iron regulation in astrocytes. Nonetheless,
brain iron is markedly elevated with aging in APP knockout mice [9]. Similar to neurons, …