Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats

LC Fox, JL Scholl, GM Palmer, GL Forster… - Experimental …, 2023 - Elsevier
Progesterone at the same dose also reduces cerebral edema after moderate-to-severe TBI
… (C) A weak correlation is present between time spent in open arms and distance traveled in …

[图书][B] Influences of Steroid Hormones on Psychological Symptoms of Mild Traumatic Brain Injury in Males and Females

LC Fox - 2019 - search.proquest.com
… future use of progesterone in males as a treatment for postconcussive anxiety or posttraumatic
progesterone decreased mRNA expression for the α-1 subunit and other GABAA receptor …

[HTML][HTML] … outcomes, and neuroprotective effect after progesterone administration in ovariectomized rats with traumatic brain injury: Role of RU486 progesterone …

L Amirkhosravi, M Khaksari, V Sheibani… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
reduces the neuroprotective effects of progesterone against oxygen-glucose deprivation/re-oxygenation-induced
In agreement with the useful role of P4 in improving anxiety after TBI in …

Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence

D Lengel, JW Huh, JR Barson, R Raghupathi - Experimental neurology, 2020 - Elsevier
… expression in brain-injured animals were correlated using … an effect of treatment wherein
progesterone decreased the … to reports that progesterone decreased anxiety-like behavior …

… cerebral blood flow mediates the relationship between progesterone and perceived stress symptoms among female collegiate club athletes after mild traumatic brain …

Y Chen, AA Herrold, V Gallagher… - Journal of …, 2021 - liebertpub.com
Correlation between PSS_Z of the mild traumatic brain injury (mTBI) group and progesterone
… We found high progesterone levels associated with lower or more normative stress …

Progesterone effects in the nervous system

V Theis, C Theiss - The Anatomical Record, 2019 - Wiley Online Library
… Preclinical studies on stroke and traumatic brain injury … effect of progesterone in young neurons
is due to reduced … regulate miRNAs that are correlated with neurodegenerative diseases. …

Sex and estrous‐phase dependent alterations in depression‐like behavior following mild traumatic brain injury in adolescent rats

LL Giacometti, JW Huh… - Journal of neuroscience …, 2022 - Wiley Online Library
declines in circulating levels of estradiol and progesterone. … TBI in early adolescence
impacted anxiety- and depression-… use in women was correlated with less severe symptoms …

Development of a novel progesterone analog in the treatment of traumatic brain injury

I Sayeed, B Wali, DB Guthrie, MT Saindane… - …, 2019 - Elsevier
… Determining the PK profile allows for a direct correlation of the … Having a much more soluble
treatment with more rapid … patients, reduced variability, and better outcome of treatment. Like …

The role of estradiol in traumatic brain injury: mechanism and treatment potential

E Kövesdi, E Szabó-Meleg, IM Abrahám - International journal of …, 2020 - mdpi.com
… A negative correlation between the circulating E2 level and the size of … and progesterone
receptors [233]. Tibolone metabolites acting on both the ERα and ERβ reduce oxidative stress …

Profiling neuroactive steroid levels after traumatic brain injury in male mice

AB Lopez-Rodriguez, E Acaz-Fonseca… - …, 2016 - academic.oup.com
… Our results showed positive correlations of brain pregnenolone and progesterone levels, but
not … that brain testosterone levels tended to decrease after trauma and presented a negative …