Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era

D Li, FL Mastaglia, S Fletcher… - Medicinal Research …, 2020 - Wiley Online Library
… therapeutics in liver disease, where miRNA mimics or antimiRs may readily enter the … miRNA
delivery across the blood–brain barrier is one of the factors that limit the progress in miRNA-…

[HTML][HTML] In vivo delivery and therapeutic effects of a microRNA on colorectal liver metastases

G Oshima, N Guo, C He, ME Stack, C Poon, A Uppal… - Molecular Therapy, 2017 - cell.com
progress to more favorable outcomes. Here, we report the effective delivery of an oligometastatic
microRNA (… Tumor-targeted microRNA miR-655-3p suppressed tumor growth when co-…

Nanoparticle mediated RNA delivery for wound healing

E Kolanthai, Y Fu, U Kumar, B Babu… - Wiley …, 2022 - Wiley Online Library
… In order to aid in the progress of wound healing, white blood cells are initiated to the wound
… Viral vectors and synthetic miRNA mimics are two tools utilized to deliver miRNA sequences …

Intracellular and extracellular microRNA: An update on localization and biological role

JA Makarova, MU Shkurnikov, D Wicklein… - Progress in …, 2016 - Elsevier
… However, miRNA is capable of entering mitochondria without ATP hydrolysis [185].
Therefore, mechanisms of AGO-miRNA delivery into mitochondria remains to be further clarified. …

Development of microRNAs as potential therapeutics against cancer

N Abd-Aziz, NI Kamaruzman, CL Poh - Journal of oncology, 2020 - Wiley Online Library
… to overcome cancer growth, miRNA delivery, and approaches to … miRNA therapy in cancers
is to deliver miRNA antagonists or … progress has been made in establishing systemic miRNA

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

K Dua, R Wadhwa, G Singhvi, V Rapalli… - Drug development …, 2019 - Wiley Online Library
… , for safe and effective delivery. siRNA mediated pro-inflammatory gene or miRNA targeting
… conditions and thus providing sustained drug delivery, reduced therapeutic dose, and …

Micelleplexes as nucleic acid delivery systems for cancer-targeted therapies

M Pereira-Silva, I Jarak, C Alvarez-Lorenzo… - Journal of Controlled …, 2020 - Elsevier
… on the recent progress on the design of new micelleplex-based systems for NA delivery, the
… ], and co-delivery of tumor suppressor let-7b miRNA mimic and hedgehog pathway inhibitor …

[HTML][HTML] MicroRNA-based therapy in animal models of selected gastrointestinal cancers

J Merhautova, R Demlova, O Slaby - Frontiers in Pharmacology, 2016 - frontiersin.org
… pharmacological aspects of miRNA-based therapy with the emphasis on delivery systems,
and … The progress of screening techniques and computational stimulation may address bright …

The risks of miRNA therapeutics: in a drug target perspective

S Zhang, Z Cheng, Y Wang, T Han - Drug design, development …, 2021 - Taylor & Francis
miRNA drugs (another therapeutic similar to siRNA drug). Here we report the existing obstacles
of miRNA … Citation29 Therefore, targeted drug delivery systems may eliminate or weaken …

Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted microRNA delivery

M Berman, G Mattheolabakis, M Suresh… - … on drug delivery, 2016 - Taylor & Francis
… Further, we consider how delivery of miRNA or … via miRNA delivery presents a novel
strategy for enhancing the efficacy of chemotherapeutics. Further, the ability to target delivery of …