[HTML][HTML] MicroRNA-based therapy for glioblastoma: Opportunities and challenges

Q Lei, Y Yang, W Zhou, W Liu, Y Li, N Qi, Q Li… - European Journal of …, 2023 - Elsevier
… This challenge has shifted gradually as progress has been … miRNA therapeutic delivery
vehicles to bypass the blood–brain barrier (BBB) with nontoxicity and immunogenicity for miRNA-…

[HTML][HTML] MicroRNA targeting to modulate tumor microenvironment

PR Kuninty, J Schnittert, G Storm, J Prakash - Frontiers in oncology, 2016 - frontiersin.org
miRNA inhibitors (antagomiR) or miRNA agonists (miR mimics). We summarize various
miRNA delivery approaches that have been or can potentially be applied to deliver miRNA as …

[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
… ]), the miRNA encoding sequences are transcribed by RNA … to generate an miRNA precursor
(pre-miRNA) of approximately 70 … The pre-miRNA hairpin is exported by exportin-5 to the …

[HTML][HTML] Recent progress in drug delivery

C Li, J Wang, Y Wang, H Gao, G Wei, Y Huang… - … pharmaceutica sinica B, 2019 - Elsevier
… During 2015–2018, significant progress in the research on drug delivery systems has been
… overview of current progress in this research area through its focus on the delivery strategies, …

Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Z Bai, J Wei, C Yu, X Han, X Qin, C Zhang… - Journal of Materials …, 2019 - pubs.rsc.org
… In this review, we will present the strategies for intracellular miRNA delivery, and specially
… new generation of delivery systems toward the emerging area of miRNA-based therapeutics …

[HTML][HTML] MicroRNA: A signature for cancer progression

BM Hussen, HJ Hidayat, A Salihi, DK Sabir… - Biomedicine & …, 2021 - Elsevier
… In spite of significant progress in understanding and knowing the basic mechanism of miRNA
biosynthesis, less is recognized about the mechanisms that control miRNA biogenesis and …

[HTML][HTML] Challenges identifying efficacious miRNA therapeutics for cancer

M Segal, FJ Slack - Expert opinion on drug discovery, 2020 - Taylor & Francis
… A substantial number of clinical trials have been conducted or are currently in progress
Another type of conjugation used for improving miRNA delivery is lipids [Citation31]. The majority …

[HTML][HTML] Therapeutic miRNA-enriched extracellular vesicles: current approaches and future prospects

J Munir, JK Yoon, S Ryu - Cells, 2020 - mdpi.com
miRNA-enriched EVs in clinics. Here, we focused on the progress in the field of therapeutic
miRNA … have been used to deliver therapeutic molecules, including miRNA, to cure certain …

[HTML][HTML] MicroRNA-based diagnosis and therapy

PTB Ho, IM Clark, LTT Le - International journal of molecular sciences, 2022 - mdpi.com
… of miRNAs have been described and extraordinary progress has been made toward finding
their … are directly conjugated to a miRNA, is a good approach for miRNA delivery. Although …

[HTML][HTML] Covalent strategies for targeting messenger and non-coding RNAs: an updated review on siRNA, miRNA and antimiR conjugates

S Grijalvo, A Alagia, AF Jorge, R Eritja - Genes, 2018 - mdpi.com
… In addition to ASOs, significant progress has been made in the field of RNAs that has led to
… siRNA and miRNA conjugates reported in the last seven years. In the case of siRNA delivery, …