MicroRNAs and their delivery in diabetic fibrosis

A Wonnacott, L Denby, RJM Coward, DJ Fraser… - Advanced drug delivery …, 2022 - Elsevier
… Altered microRNA expression profiles have been observed both in diabetes and in diabetic
complications. These transcripts therefore have significant potential and novelty as targets …

microRNAs as cancer therapeutics: A step closer to clinical application

TC Ivkovic, G Voss, H Cornella, Y Ceder - Cancer letters, 2017 - Elsevier
… Another group of broadly used carriers for miRNA delivery are the biocompatible and
biodegradable liposomes. They mimic the phospholipidic membrane of the human cells, allowing …

Research progress of microRNA and its non-viral vector in intervertebral disc degeneration

Y Huang, G Feng, L Liu, T Li, H Liu… - … xiu fu Chong Jian wai ke …, 2017 - europepmc.org
… can regulate the related gene expression level and further participate in the pathophysiologic
process in degenerated intervertebral disc, miRNA delivered by various non-viral vectors …

Tackling aging by using miRNA as a target and a tool

WF Lai, M Lin, WT Wong - Trends in molecular medicine, 2019 - cell.com
miRNA in modulating the aging process. We discuss major chemical techniques for modifying
the miRNA structure as well as developing delivery … -to-clinic translation of miRNA-based …

The linkage between microRNA and cancer and its delivery as cancer therapy: A mini-review

SUFS Najmuddin, AA Kamarudin, SA Sani… - Cellular and Molecular …, 2023 - cellmolbiol.org
… As a result, the current progress of treatment intervention focuses on modifying the miRNA
outlining the role of miRNA in cancer as well as its mode of delivery which includes liposomes…

Artificial miRNAs as therapeutic tools: Challenges and opportunities

A Kotowska‐Zimmer, M Pewinska… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
… and scaffold based on a natural primary miRNA (pri-miRNA). siRNAs serve as a guide to …
have yielded progress in the development of viral vectors; however, the effective delivery of …

[HTML][HTML] Advances in RNA cancer therapeutics: New insight into exosomes as miRNA delivery

L Volpini, F Monaco, L Santarelli, J Neuzil… - Aspects of Molecular …, 2023 - Elsevier
… exosomes for miRNA delivery, focusing on new approaches to overcome the limits of miRNA-…
Little progress has been achieved by a collaboration between EnGeneIC and the Asbestos …

Current status of microRNA-based therapeutic approaches in neurodegenerative disorders

S Paul, LA Bravo Vázquez, S Pérez Uribe… - Cells, 2020 - mdpi.com
miRNA dysregulations related to the onset and progress of NDDs, and the novel miRNA-…
in which overexpression of miRNA-16 was achieved in mice brains through the delivery of …

The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives

H Walgrave, L Zhou, B De Strooper, E Salta - Molecular …, 2021 - Springer
MicroRNA research has come a long way from their initial … the knowledge on microRNA
regulation in Alzheimer’s … the development of microRNA-based therapeutics in the clinic. …

miRNA nanotherapeutics for cancer

A Ganju, S Khan, BB Hafeez, SW Behrman… - Drug discovery today, 2017 - Elsevier
… We report successful microRNA nano-mediated delivery for the treatment of cancer. …
NP-encapsulated delivery of miRNA for pancreatic cancer treatment remains an unexplored field …