MicroRNA based theranostics for brain cancer: basic principles

GED Petrescu, AA Sabo, LI Torsin, GA Calin… - Journal of experimental …, 2019 - Springer
… of approximately 7 years, but ultimately, they progress to high grade gliomas (HGG, WHO
grade … b The methods to achieve miRNA restoration therapies can be direct: delivery of miRNA

Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

L Jiang, P Vader, RM Schiffelers - Gene Therapy, 2017 - nature.com
… vehicles for RNA delivery, but clinical progress has been limited as a … delivery efficiency
as compared with the synthetic systems, has provided a ray of hope in coping with the delivery

Development of microRNA-based therapy for pancreatic cancer

A Fesler, J Ju - Journal of pancreatology, 2019 - journals.lww.com
… made some great progress in treating several … miRNA can also be delivered to tumor cells
vehicle free. This is a major advancement that may help to overcome the bottleneck of delivery

[HTML][HTML] Modulating microRNAs in cancer: Next-generation therapies

N Arghiani, K Shah - Cancer Biology & Medicine, 2022 - ncbi.nlm.nih.gov
… have focused on optimizing strategies for miRNA delivery to tumor sites, as … progress of
therapeutic miRNA delivery systems. We also discuss the challenges and advances in miRNA-…

At the intersection of biomaterials and gene therapy: progress in non-viral delivery of nucleic acids

H Uludag, A Ubeda, A Ansari - Frontiers in bioengineering and …, 2019 - frontiersin.org
… Biomaterials play a critical role in technologies intended to deliver therapeutic agents in …
We first review various types of nucleic acids and their unique abilities to deliver a range of …

Delivering miRNA modulators for cancer treatment

M Estanqueiro, H Vasconcelos, JMS Lobo… - … sensitive drug delivery …, 2018 - Elsevier
… developed to deliver miRNA modulators to cancer cells. … the potential therapeutic role of
miRNA modulators in cancer … the delivery of either miRNA mimics or miRNA inhibitors to the …

[HTML][HTML] RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA

Q Leng, L Chen, Y Lv - Theranostics, 2020 - ncbi.nlm.nih.gov
… are described with a focus on the methods of miRNA delivery. … to deliver miRNA to the
cytoplasm, while lipids and liposome analogues are most commonly applied to deliver miRNA to …

Nanocarrier-based co-delivery of small molecules and siRNA/miRNA for treatment of cancer

D Chitkara, S Singh, A Mittal - Therapeutic Delivery, 2016 - Taylor & Francis
… agent could be delivered along with oligonucleotide/s (siRNA/miRNA) to achieve better …
However, several challenges hinder the progress of co-delivery formulations. miRNA/siRNA …

MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
… the application is to develop an effective delivery system, like the nanoparticles, lipid …
Progress of miRNA-Related Drugs In recent 20 years, the field of miRNA has made rapid progress

Galactose-modified nanoparticles for delivery of microRNA to mitigate the progress of abdominal aortic aneurysms via regulating macrophage polarization

X Chen, Y Wu, R Li, C Li, L Xu, W Qiao… - … , Biology and Medicine, 2022 - Elsevier
… Briefly, microRNA mimics or microRNA scramble control, … Firstly, solution microRNA mimics
or microRNA scramble … ratio of weight of microRNA mimics or microRNA scramble control to …