Differential mechanisms of de-regulated bone formation in rheumatoid arthritis and spondyloarthritis
SR Goldring - Rheumatology, 2016 - academic.oup.com
… The sost gene is regulated in part by mechanical factors and soluble mediators such as …
They then showed that overexpression of IL-23 induced a destructive enthesitis with …
They then showed that overexpression of IL-23 induced a destructive enthesitis with …
Bone formation in axial spondyloarthritis: Is disease modification possible?
A Nakamura, A Talukdar, S Nakamura, E Pathan… - Best Practice & …, 2019 - Elsevier
… A more recent Chinese study of CT guided needle biopsies from … evidence from clinical,
genetic and mechanical studies also … IL-23-induced inflammation to bone growth in the enthesis. …
genetic and mechanical studies also … IL-23-induced inflammation to bone growth in the enthesis. …
Enthesopathies–Mechanical, inflammatory or both?
R Sabido-Sauri, X Baraliakos, SZ Aydin - Best Practice & Research Clinical …, 2024 - Elsevier
… shown that patients with axial spondyloarthritis (axSpA) can … A critical outcome of the repair
process is new bone formation… has a mechanical enthesopathy vs "inflammatory enthesitis". It …
process is new bone formation… has a mechanical enthesopathy vs "inflammatory enthesitis". It …
Bone marrow mesenchymal stem cells in rheumatoid arthritis, spondyloarthritis, and ankylosing spondylitis: problems rather than solutions?
JM Berthelot, B Le Goff, Y Maugars - Arthritis research & therapy, 2019 - Springer
… bone marrow stem cells also invade the soft tissue side of enthesis via small holes in the bone
… does not fit well with the mechanical strain hypothesis. The uneven distribution of arthritis/…
… does not fit well with the mechanical strain hypothesis. The uneven distribution of arthritis/…
Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with
… changes may represent the early stages of periostitis and new bone formation, typical of
SpA.4 As early as 1959, Cava postulated mechanical stress may contribute to enthesitis.5 In ‘…
SpA.4 As early as 1959, Cava postulated mechanical stress may contribute to enthesitis.5 In ‘…
[HTML][HTML] Molecular mechanisms of new bone formation in axial spondyloarthritis
K Klavdianou, A Kanellou… - Mediterranean Journal of …, 2022 - cyberleninka.ru
… to stress either mechanical, such as the enthesis or microbial, such … Axial spondyloarthritis
(axSpA) is typically characterised by … that new bone formation is driven by mechanical strain. …
(axSpA) is typically characterised by … that new bone formation is driven by mechanical strain. …
Born to run: the paradox of biomechanical force in spondyloarthritis from an evolutionary perspective
K Debusschere, I Cambré, E Gracey… - Best Practice & Research …, 2017 - Elsevier
… This article introduces the concept of the enthesis as a … mechanical force is discussed before
examining enthesitis from a … the development of new bone formation might not depend on …
examining enthesitis from a … the development of new bone formation might not depend on …
The paradox of bone formation and bone loss in ankylosing spondylitis: evolving new concepts of bone formation and future trends in management
… from Achilles tendons of spondyloarthritis (SpA) patients. … Mechanical loading (ML) of the
bone mediates activation of … formation of new cartilage and bone at the enthesis [30]. This …
bone mediates activation of … formation of new cartilage and bone at the enthesis [30]. This …
Role of the IL-23 pathway in the pathogenesis and treatment of enthesitis in psoriatic arthritis
M Rossini, OM Epis, I Tinazzi… - Expert Opinion on …, 2020 - Taylor & Francis
… , gut dysbiosis, and mechanical stress. We also review clinical … , or enthesitis, is the hallmark
of the spondyloarthritis (SpA) … New bone formation was also observed at the entheses in …
of the spondyloarthritis (SpA) … New bone formation was also observed at the entheses in …
The early phases of ankylosing spondylitis: emerging insights from clinical and basic science
… to an aberrant new bone formation or downstream effect of IL-… greater magnitude than the
mechanically driven disease (29)… causes a florid enthesitis which is driven by enthesis resident …
mechanically driven disease (29)… causes a florid enthesitis which is driven by enthesis resident …