… The sost gene is regulated in part by mechanical factors and soluble mediators such as …
They then showed that overexpression of IL-23 induced a destructive enthesitis with …

… A more recent Chinese study of CT guided needle biopsies from … evidence from clinical,
genetic and mechanical studies also … IL-23-induced inflammation to bone growth in the enthesis. …

… shown that patients with axial spondyloarthritis (axSpA) can … A critical outcome of the repair
process is new bone formation… has a mechanical enthesopathy vs "inflammatory enthesitis". It …

… bone marrow stem cells also invade the soft tissue side of enthesis via small holes in the bone
… does not fit well with the mechanical strain hypothesis. The uneven distribution of arthritis/…

… changes may represent the early stages of periostitis and new bone formation, typical of
SpA.4 As early as 1959, Cava postulated mechanical stress may contribute to enthesitis.5 In ‘…

… to stress either mechanical, such as the enthesis or microbial, such … Axial spondyloarthritis
(axSpA) is typically characterised by … that new bone formation is driven by mechanical strain. …

… This article introduces the concept of the enthesis as a … mechanical force is discussed before
examining enthesitis from a … the development of new bone formation might not depend on …

… from Achilles tendons of spondyloarthritis (SpA) patients. … Mechanical loading (ML) of the
bone mediates activation of … formation of new cartilage and bone at the enthesis [30]. This …

… , gut dysbiosis, and mechanical stress. We also review clinical … , or enthesitis, is the hallmark
of the spondyloarthritis (SpA) … New bone formation was also observed at the entheses in …

… to an aberrant new bone formation or downstream effect of IL-… greater magnitude than the
mechanically driven disease (29)… causes a florid enthesitis which is driven by enthesis resident …