… types based on microscopic features: small-cell lung cancer (… EGFR TKI-resistant cells during
EGFR TKI treatment may … primary drug resistance to a large number of cancer cell lines by …

… studies to generally describe the features, potential origins, … an optimal treatment for
EGFR-mutated lung cancer will require … that each EGFR-mutated lung cancer cell line may employ …

… acquired resistance to 3rd generation EGFR inhibitors is critical … expressed in resistant cell
lines generated by treatment with … cells can have similar characteristics to the parental cells in …

… experience with EGFR inhibitors in lung cancer, drug resistance, … in the first-line treatment
of EGFR-mutant lung cancer (11, 12). … Early work with a gefitinib-sensitive lung cancer cell line …

… Indeed, EMT features in the erlotinib-resistant cell lines were … positive cells resulted by the
comparison of cell lines treated … a 500 μm wide cell-free gap (wound) was generated. The dish …

… target for the treatment of EGFR TKI-resistant lung cancer. In … -resistant and two
erlotinib-sensitive lung cancer cell lines. Both … -27 on cells resistant to the third-generation EGFR …

… Given these properties, 1G and 2G EGFR-TKIs for several … cases treated with this drug as
second line become resistant within … investigations in NSCLC cell lines and animal models that …

… gene (EGFR)-mutated non–small cell lung cancer (NSCLC). … process in which cells lose
their epithelial features and acquire … that EGFR T790M mutation emerged only in tumors treated …

… features and suggest that dual EGFR + FGFR inhibition may be … to re-sensitize mesenchymal
cell lines to EGFR inhibition, we … EGFR-mutant NSCLC cells to EGFR inhibitors, we treated …

… lung cancer treatment results in enormous number of saved lives. Clinical development of
EGFR inhibitors … ; and mesenchymal cell lines were more resistant to the compounds inhibiting …