… The aim of this study was to validate the sensitivity and specificity of the updated BIG (uBIG) …
Prospective validation of the brain injury guidelines: managing traumatic brain injury without …

… in traumatic brain injury (TBI) patients. The aim of this study was to prospectively validate …
Among approximately 2,000 TBI patients presenting to 10 trauma centers, no BIG 1 or BIG 2 …

… a single center prospective validation of the guidelines in 2014… mBIGs, although the two
guidelines are not identical, and the … the BIG were not actually implemented in that prospective …

… and streamlined guidelines for prospective validation and … , without changing care protocols,
allowed validation within the local trauma system and refinement of the original BIG criteria …

… Individuals were excluded from a given analysis year, and future years, if they had not … of
future uncertainty. Future research is needed to assess external validity in separate cohorts. …

… is defining and shaping the future, and proposes a solution in … to assessing the internal validity
or quality of studies. The … protocols we know in advance will not produce strong evidence? …

… Guidelines for temperature control were not addressed in this … of French guidelines on
targeted temperature management in the … 6681 and 8509 patients, have validated these criteria. …

… aware of any data used in the present study that were missing not at random. Thus, we used
… brain imaging or the use of biomarkers for brain damage. Future external validation will be …

… The modified Brain Injury Guidelines refine the originalguidelines to enhance reproducibility
… Prospective validation of the brain injury guidelines: managing traumatic brain injury without …

… models at external validation due to missing predictor data were not defined as separate …
Cohorts for model development were mostly single center and prospective, with a median …