… PTEN locus might affect more than PTEN itself and lead to the deletion of other tumor suppressor
genes … The prostate-specific loss of Pten PCa mouse model (Pten flox/flox ;PB-Cre4 + ) …

… Loss of function of the tumor suppressor PTEN is closely associated with prostate … that
prostate-specific expression of NICD (the ARR2PB-Cre ROSA26-LSL-NICD Mut/Wt model) led to …

… Pten deletion to the prostatic epithelial layer 24 . Pten deletion leads to enlarged prostate …
MiR-375, also identified as a tumour suppressor 40 showed a strong downregulation our …

… the PTEN tumour suppressor and its relationship to prostate … partly due to the fact that the
frequency of PTEN deletion is highly … deletion of Pten, Rb1, and Tp53 in the mouse prostate is …

… mouse prostate tumor models (GEMMs) based on targeted bi-allelic deletion of the Pten tumor
suppressor gene … of Pten in the mouse prostate leads to prostate cancer accompanied by …

… mouse Trp53 and Pten alone does not result in rapid development of prostate tumors; however,
combined inactivation leads … as time to prostate-specific antigen relapse, metastasis, or …

… and I), and downregulation of the tumor suppressor Nkx3.1 was … MYC expression combined
with Pten loss leads to metastatic … with loss of Pten in mouse prostatic luminal epithelial cells, …

… leukemia 4 and a tumor suppressor in skin cancer. Notch signaling … with a prostate specific
Pten deletion mouse model for prostate … suppressor gene leads to metastatic prostate cancer. …

… PTEN is a tumor suppressor gene and one of the most … PTEN deletion has been highly
linked to inflammation, in … role of PTEN in PCa, a PTEN prostate-specific deletion mouse model …

… new mouse model (PSGR-Pten Δ/Δ ) combining prostate-specific … suppressor gene leads
to metastatic prostate cancer. … is a tumor suppressor and proliferator in prostate cancer. Proc …