… expressing monoclonal antibodies (MAb) recognizing rotavirus … To directly compare the
relative potency of VP6-specific IgA … Fc region would have no effect on neutralisation within cells. …

… neutralizing Abs [34,35], although VP6-specific IgA mAbs … the protection of combined orally
administered VP6-specific VHH (… VHH antibody fragments and mouse monoclonal antibodies. …

… , both, or neither of the monoclonal antibodies (mAbs) 255/60 … elicited high titres of VP6-specific
mucosal IgA and serum IgG.… , several VP6-specific mAbs which lack neutralizing activity …

… Results primarily from monoclonal antibody (mAb) studies … However, these mAbs do not
have in vitro neutralization … -based neutralization data, negative control VP6-specific human …

… of antibody repertoires, monoclonal antibody expression, and … heterotypic protection in
vivo, although they lack neutralizing … of VP6-specific IgA + ASCs as a proportion of total IgA + …

… protective-transfer using systemic administration of a dimeric IgA (dIgA) monoclonal antibody.
… 1, 3 and 5 days post injection via a RV VP6-specific IgA antibody ELISA. The 5 mg/kg (x) …

… neutralizing antibodies against these pathogens [16, 17]. … VP6, while the his-tag and rFerritin
won’t induce VP6 specific … immunogenicity and protective effects against rotavirus can result …

… induce the production of neutralizing antibodies that confer protection, anti-VP6 IgA … IgA
antibodies were detected in the intestinal lumen. On the contrary, high levels of VP6-specific IgA …

… induced the highest titration of VP6-specific IgG and IgA responses compared to the … protective
antibodies (Abs) even without any neutralizing (NT) activity (10,20,26). In fact, non-NT IgA …

… Finally, since mouse IgG1 showed no protective effect in mice, we excluded an effect of Fc
… Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6-specific IgA mAb. The …