The potential of stimulating nitric oxide formation in the treatment of hypertension

LC Pinheiro, JE Tanus-Santos… - Expert opinion on …, 2017 - Taylor & Francis
… eNOS expression, and reverses its uncoupling state. This … In fact, nebivolol acts as an agonist
of endothelial β 3 receptor in … causes of endothelial dysfunction and the relationship with …

Diverse pharmacological properties, trial results, comorbidity prescribing and neural pathophysiology suggest European hypertension guideline downgrading of beta …

M Esler, SE Kjeldsen, A Pathak, G Grassi, R Kreutz… - … Pressure, 2022 - Taylor & Francis
… fully exploiting the documented protective effect of BP lowering “per … SNS is modulating
endothelial function. In free-moving … , sustained release metoprolol and nebivolol to be the beta-…

A review of chemical therapies for treating diabetic hypertension

PA Sarafidis, ME Alexandrou… - Expert opinion on …, 2017 - Taylor & Francis
… Beneficial metabolic effects of nebivolol relative to metoprolol were shown in recent
studies … Odds ratios to the left of the vertical line denote a protective effect. Individual pair-wise …

Epicatechin's cardiovascular protective effects are mediated via opioid receptors and nitric oxide

K MacRae, K Connolly, R Vella, A Fenning - European journal of nutrition, 2019 - Springer
… commonly associated with obesity, hypertension and diabetesassociated with CVD results
in impaired endothelial function, … to reverse elevated blood pressure in chronic hypertensive

Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs

D Terentes-Printzios, N Ioakeimidis, K Rokkas… - Nature Reviews …, 2022 - nature.com
… risk factors, including hypertension, diabetes mellitus, obesity and … The association between
endothelial dysfunction and … In terms of effects on erectile function, the β-blocker nebivolol

Repurposing medications for treatment of pulmonary arterial hypertension: what's old is new again

KW Prins, T Thenappan, EK Weir, R Kalra… - … Heart Association, 2019 - Am Heart Assoc
… to halt or even reverse pulmonary hypertension in animal studies, … antagonists could combat
endothelial dysfunction, prevent … The mechanistic underpinnings of the protective effects of …

Nebivolol effect on doxorubicin-induced cardiotoxicity in breast cancer

F Cochera, D Dinca, DA Bordejevic… - Cancer management …, 2018 - Taylor & Francis
… of arterial hypertension and cardiac insufficiency and it could have beneficial effects in …
This study evaluated the protective role of nebivolol against the occurrence of anthracycline-…

Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension

SI Dikalov, AE Dikalova - Antioxidants & redox signaling, 2019 - liebertpub.com
endothelial dysfunction and hypertension. Indeed, we have found that hypertension is
associated … with cell aging, as measured by diminished telomerase reverse transcriptase (hTERT) …

Targeting Central Blood Pressure Through the Macro-and Microcirculation Cross-Talk

S Laurent, RM Bruno, C Agabiti-Rosei… - Early Vascular Aging …, 2024 - Elsevier
… class can reverse the vicious circle of … effects of the newer β-blockers, such as nebivolol,
bisoprolol, or carvedilol, which, theoretically, could have different properties and different effects, …

Mirabegron, a selective β3-adrenoceptor agonist causes an improvement in erectile dysfunction in diabetic rats

D Yilmaz-Oral, E Kaya-Sezginer… - … & Diabetes, 2021 - thieme-connect.com
… nerve, penile endothelial dysfunction, and veno-… that nebivolol was beneficial in the treatment
of diabetic neuropathy [15]. A study by Oikawa et al. [16] demonstrated protective effects of …