Proteomic analysis of tears in dry eye disease: A prospective, double-blind multicenter study
GT Jung, M Kim, JS Song, T Im Kim, TY Chung… - The Ocular Surface, 2023 - Elsevier
Purpose To identify specific dry eye disease (DED) tear biomarker (s) using tear proteomic
analysis, clinical parameters, and their correlations before and after DED treatment. Methods
A prospective, double-blinded, national multicenter clinical study was performed using data
from 80 DED patients. The patients were treated with 0.1% cyclosporine (CsA, n= 28), 0.05%
CsA (n= 26), or 3% diquafosol (DQS, n= 26) eye drops, and tear proteome changes and
clinical outcomes (tear break-up time [TBUT], corneal erosion [Cor-Er], conjunctival erosion …
analysis, clinical parameters, and their correlations before and after DED treatment. Methods
A prospective, double-blinded, national multicenter clinical study was performed using data
from 80 DED patients. The patients were treated with 0.1% cyclosporine (CsA, n= 28), 0.05%
CsA (n= 26), or 3% diquafosol (DQS, n= 26) eye drops, and tear proteome changes and
clinical outcomes (tear break-up time [TBUT], corneal erosion [Cor-Er], conjunctival erosion …
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