… (B) of all soluble samples reveal specific effects on the proteome driven by the genotype,
age, … (C) Hierarchical clustering of protein expression over time shows substantial proteome …

… activation was detected in the striatum of asymptomatic R5/2 mice, likely indicating that
neuroinflammation … is the first study investigating the proteomic profiles of Cypriot HD patients and …

… Our findings revealed several new biomarker candidates … Similar to the previous metabolomics
studies, our proteomics … may result from the activation of a compensatory mechanism to …

… Interestingly, HTT shows structural similarities to three … shown to be upregulated in the plasma
of HD patients [99] and … , enhanced neuroinflammatory response and dysregulation of iron …

… reactive morphology causing neuroinflammation and gliosis. … For global proteome profiling,
data-dependent acquisition (DDA) … This study revealed decreased levels of peroxiredoxin-3 (…

… family 18 and a marker of microglial activation [59], was … elevation in other diseases associated
with neuroinflammation [60]. … spectrometry to analyze the proteomic profile of CSF from 39 …

… Neuroinflammation has been shown to be an important factor and microglial activation can
… In 2007, Dalrymple and colleagues presented an unbiased proteomics screen of HD plasma …

… In vivo experiments have revealed that the ectopic overexpression of mutant … It is possible
that the activation of microglia and astroglia … were shown in HD patient plasma and CSF (37). …

… activation of the metabotropic glutamate receptor 5, which is involved in neuroinflammation
(… preparations, shotgun proteomic profiling experiments have started to reveal the families of …

… studies revealed that the inhibition of the ubiquitin-activating … induces transcriptional and
proteomic changes that lead to … that although neuroinflammation and microglia activation are …