Identification of novel key molecular signatures in the pathogenesis of experimental diabetic kidney disease

M Diao, Y Wu, J Yang, C Liu, J Xu, H Jin… - Frontiers in …, 2022 - frontiersin.org
ketogenic activity and down-regulated ketolytic activity in … was more likely to work as a
ketogenic organ rather than a ketolytic organ. … Proteomics Analysis Reveals Diabetic Kidney as a …

HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk

SK Shukla, W Liu, K Sikder, S Addya, A Sarkar, Y Wei… - Scientific reports, 2017 - nature.com
… Figure 5B shows that after diabetes induction, AKT and ERK … HMGCS2 expression is organ
specific or other vital organs also … renal ketogenesis which ultimately leads to the diabetic

Role of ketogenic starvation sensors in mediating the renal protective effects of SGLT2 inhibitors in type 2 diabetes

M Packer - Journal of Diabetes and its Complications, 2020 - Elsevier
… This possibility is particularly relevant to organ protection, since the effect of SGLT2 … favorable
effects in the diabetic kidney by promoting ketogenic nutrient deprivation signaling through …

Proteomic study on the new potential mechanism and biomarkers of diabetes

N Wang, S Zhang, F Zhu, Y Yang… - PROTEOMICS …, 2019 - Wiley Online Library
kidneys, nerves, cardiovascular, limbs, and other organs.1, 2 … By studying the renal cortical
proteome in db/db diabetic mice… , causing severe hypoglycemia, ketosis, and lactic acidosis. …

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease

C Granata, V Thallas-Bonke, N Caruana, K Huynh… - bioRxiv, 2023 - biorxiv.org
… This was supported by a decrease in MFN2 observed in our proteomic analysis (discussed in
… As introduced above, our proteomics analysis shows dysregulation of solute carriers, some …

Metabolomics profiling of patients with A− β+ ketosis-prone diabetes during diabetic ketoacidosis

F Jahoor, JW Hsu, PB Mehta, KR Keene, R Gaba… - Diabetes, 2021 - Am Diabetes Assoc
… Though acylcarnitines are formed intracellularly in all organs and tissues except brain, there
is … Thus, comparative serum metabolomics analysis reveals complex defects in pathways of …

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in …

S Nasser, T Solé, N Vega, T Thomas, A Balcerczyk… - Molecular …, 2022 - Elsevier
… , suggesting that the kidney may be a ketogenic organ. … diet induces extensive transcriptional
and proteomic responses … in mildly obese type 2 diabetic patients, although ketosis was …

Key enzyme in charge of ketone reabsorption of renal tubular SMCT1 may be a new target in diabetic kidney disease

Z Guo, F Zhong, M Hou, J Xie, AZ Zhang… - Nephrology Dialysis …, 2023 - academic.oup.com
… A ketogenic diet or mildly increased ketone body levels are … We carried out transcriptomics
and proteomics analysis to ex… for important organs such as the brain, heart and kidneys [7…

Metabolic Regulation in Diabetic Kidney Disease

J Baek - 2024 - deepblue.lib.umich.edu
… the kidney cortex of the type 2 diabetic T2D db/db mice and that this process is regulated by
Sirtuin … Proteomic analysis of db/db and db/+ kidney cortex found that targets with significant …

[PDF][PDF] Proteomic approaches to the study of renal mitochondria.

Z Tuma, J Kuncova, J Mares… - … Papers of the …, 2016 - pdfs.semanticscholar.org
Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. …
Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick …