Challenging identification of polymorphic mixture: Polymorphs I, II and III in olanzapine raw materials

CG Testa, LD Prado, RN Costa, ML Costa… - International journal of …, 2019 - Elsevier
… by conventional techniques such as powder X-ray diffraction, thermoanalytical techniques, …
The quantification of related substances A and B of OLZ and dosing were performed by high …

Olanzapine form IV: Discovery of a new polymorphic form enabled by computed crystal energy landscapes

S Askin, JK Cockcroft, LS Price… - Crystal Growth & …, 2019 - ACS Publications
… DSC–powder X-ray diffraction (PXRD) analytical technique was … powder X-ray diffraction
patterns of the known olanzapine … as olanzapine but also facilitate determination of the crystal

A simultaneous differential scanning calorimetry–X-ray diffraction study of olanzapine crystallization from amorphous solid dispersions

S Askin, AD Gonçalves, M Zhao… - Molecular …, 2020 - ACS Publications
X-ray diffraction to monitor the sequential appearance of polymorphs of olanzapine (OLZ) …
Recent work has developed methods to understand and quantify OLZ crystallization from …

Role of moisture on the physical stability of polymorphic olanzapine

MC Paisana, MA Wahl, JF Pinto - International Journal of Pharmaceutics, 2016 - Elsevier
… , infrared (DRIFT) and X-ray powder diffraction. The results showed … a powerful technique for
identification, characterization and … The quantification of olanzapine hydrate conversion was …

Rational crystal polymorph design of olanzapine

H Luo, X Hao, Y Gong, J Zhou, X He… - Crystal Growth & Design, 2019 - ACS Publications
… , the crystal polymorph calculations are carried out using the … method for the olanzapine
molecule and generated a range of hypothetical crystal structures with low lattice energies using

Production and mechanistic evalution of the stability of polymorphic olanzapine in solid dosage forms

MC Paisana - 2016 - repositorio.ul.pt
… several techniques, such as a combination of thermal analysis … with different excipients (as
powders or compacts) that present … for crystal structure determination by X-ray diffraction (34). …

Mechanochemical synthesis of olanzapine salts and their hydration stability study using powder X-ray diffraction

KK Sarmah, P Sarma, DR Rao, P Gupta… - Crystal Growth & …, 2018 - ACS Publications
… The method has been used to synthesize materials such as … data for OLN–SA salt did
not permit structure determination. … to OLN monohydrate and dihydrate polymorphs. Peaks …

Crystal structure determination of the antipsychotic drug of olanzapine form III.

G Anyfanti, E Husanu, I Andrusenko, D Marchetti… - bioRxiv, 2024 - biorxiv.org
… single crystal and powder X-ray diffraction (PXRD) analysis, … two complementary techniques
for its structure determination. In … how olanzapine crystals of the same polymorph can adopt …

Production and mechanistic evalution of the stability of polymorphic olanzapine in solid dosage forms

M de Castro Paisana - 2016 - search.proquest.com
… several techniques, such as a combination of thermal analysis … with different excipients (as
powders or compacts) that present … for crystal structure determination by X-ray diffraction (34). …

Identification and quantification techniques of polymorphic forms-A review

JT Chambi, C Fandaruff, SL Cuffini - … and Biomedical Analysis, 2024 - Elsevier
… To this study, the powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC),
Infrared … Olanzapine Forms I and II Raw material Calibration curve and validation analytical …