After a brief history that positions polymerization‐induced self‐assembly (PISA) in the field of
polymer chemistry, this Review will cover the fundamentals of the PISA mechanism.
Furthermore, this Review will also give an overview of some of the features and limitations of
RAFT‐mediated PISA in terms of the choice of the components involved, the nature of the
nanoobjects that can be obtained and how the syntheses can be controlled, as well as some
potential applications.

Polymerization-induced self-assembly (PISA) combines polymerization and self-assembly in
a single step with distinct efficiency that has set it apart from the conventional solution self-
assembly processes. PISA holds great promise for large-scale production, not only because
of its efficient process for producing nano/micro-particles with high solid content, but also
thanks to the facile control over the particle size and morphology. Since its invention, many
research groups around the world have developed new and creative approaches to …