… ) are effective bronchodilators that … gene expression changes could explain the known
toxicity of chronic, β2adrenoceptor agonist monotherapy initially reported in patients with asthma …

… We have focused on the role of the R4 subfamily of RGS proteins in asthma. The R4 … in
Rgs5 was linked to severe asthma in children who responded poorly to bronchodilators (12). …

… RGS5 higher in ASM from asthma patients and in allergen-challenged mice compared to …
Current therapies directly targeting ASM are squarely focused on promoting bronchodilation (…

… as a bronchodilator, has anti-inflammatory actions. Some … Regulators of G protein
signaling (RGS) proteins restrict … Collectively, our findings suggest that acute upregulation of …

… fatal asthma patients as compared with that derived from non-… of the receptor3,4, genetic
polymorphisms altering receptor … cell lines that overexpress the RGS domain of p115RhoGEF, …

The nongenomic mechanisms by which glucocorticoids modulate β 2 agonist-induced-bronchodilation
remain elusive. Our studies aimed to elucidate mechanisms mediating the …

… are stimulated in patients with asthma. Increased expression … of a G 12 inhibitor (p115RhoGEF-RGS)
suppressed carbachol-… in the promoter region of genes involved in pro-proliferative …

… , topical therapy of asthmatic patients with calcilytics has the … therapy to replace conventional
bronchodilator therapy for … once or twice daily to adults and children in a limited range of …

… a combination of pharmacotherapy (short and long acting NRT’s) … The regulator of G protein
(RGS) has recently been reported … However, bronchodilator reversibility was seen in patients …

… bronchodilators are GPCR ligands which exert their action by … therapy for acute bronchospasm
and combined long-acting β… -G protein coupling, RGS function, and structural biology of …