ROCK2 regulates monocyte migration and cell to cell adhesion in vascular endothelial cells

Y Takeda, K Matoba, D Kawanami, Y Nagai… - International journal of …, 2019 - mdpi.com
… Activation of the Rho/ROCK pathway leads to the phosphorylation of downstream substrates…
that ROCK2 deficiency in bone marrow-derived cells showed substantially reduced lipid …

ROCK as a therapeutic target for ischemic stroke

N Sladojevic, B Yu, JK Liao - Expert review of neurotherapeutics, 2017 - Taylor & Francis
… single and double deficiency of ROCK1 and ROCK2 lead to … more rapidly, leading to
decreased cerebral injury and lowerBone marrow-derived ROCK1-deficient macrophages have …

Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets

N Sladojevic, GT Oh, HH Kim… - Cardiovascular …, 2017 - academic.oup.com
… heart, monocytes, or other bone marrow-derived cells (n = 5, Figure 1… Because ROCK2
deficiency in platelets leads to decreasedcholesterol transport and cholesterol efflux, 34 ROCK2-…

Context-dependent signalling in platelets in vascular diseases: ROCK2 around thrombosis

JG Filep - Cardiovascular Research, 2017 - academic.oup.com
… An unexpected observation in this study was the failure of ROCK2-deficient platelets to …
deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased

Targeting ROCK signaling in health, malignant and non-malignant diseases

R Shahbazi, B Baradaran, M Khordadmehr, S Safaei… - Immunology letters, 2020 - Elsevier
… which apoptosis has been decreased in the cardiac cells [26]… -activated receptor-g-dependent
cholesterol efflux [32]. Fig. 3 … mutations in ROCK2 can lead to increased kinase activity [9]. …

[PDF][PDF] Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia

H Bai, J Sun, G Du, F Jiao - Archives of Medical Science, 2017 - termedia.pl
… lowering induced by moderate aerobic exercise may have led to reduced leukocyte ROCK2
deficiency in bone marrowderived cells leads to increased cholesterol efflux and decreased

Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system

A Cai, L Li, Y Zhou - Journal of Hypertension, 2016 - journals.lww.com
… similarity, the pathophysiological roles of ROCK1 and ROCK2 … of ROCK1 in bone
marrow-derived cells retards … AI-mediated cholesterol efflux, thus favoring foam cells formation …

Rho/Rho Kinase Signaling Pathway and Disease: from Bed to Bench

Y Wang, Y Zhang, D Zhang - Frontiers in Cardiovascular Drug …, 2022 - books.google.com
… to make and can potentially lead to … , bone marrowderived cells of Rock2 deletion or
haploinsufficiency transplantation into Ldlr −/− mice also protects from atherosclerosis and reduces

[PDF][PDF] ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells.

竹田裕介 - International journal of molecular sciences, 2021 - ir.jikei.ac.jp
… Activation of the Rho/ROCK pathway leads to the phosphorylation of downstream substrates…
that ROCK2 deficiency in bone marrow-derived cells showed substantially reduced lipid …

ROCK inhibition may stop diabetic kidney disease

K Matoba, Y Takeda, Y Nagai, Y Kanazawa… - JMA journal, 2020 - jstage.jst.go.jp
… to impaired closure of the eyelids and umbilical ring in mice (6), whereas ROCK2 deficiency
deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased