[HTML][HTML] New insights on stem cells modeling and treatment of human diseases
… in autoimmunity and involved in the regulation … inhibit Th1 and Th17 cell proliferation along
with a reduced level of IL-17, IL-2, IL-6, and IFN- gamma and downregulate T cell activation …
with a reduced level of IL-17, IL-2, IL-6, and IFN- gamma and downregulate T cell activation …
Mechanisms of autoimmunity
B Antiochos, A Rosen - Clinical immunology, 2019 - Elsevier
… a striking lupus-like phenotype (reviewed in Rai and Wakeland 11 ). Together, the data …
stimulatory and inhibitory signaling in effector and Tregs, favoring effector T-cell activation. …
stimulatory and inhibitory signaling in effector and Tregs, favoring effector T-cell activation. …
[HTML][HTML] Dendritic cells expressing triggering receptor expressed on myeloid cells-1 correlate with plaque stability in symptomatic and asymptomatic patients with …
… Indeed, there is heterogeneity within the phagocytic cell … capacity for antigen presentation
and stimulation of T cell activation [3]. … for one hour in blocking solution/permeabilizing solution …
and stimulation of T cell activation [3]. … for one hour in blocking solution/permeabilizing solution …
[HTML][HTML] Clinical implication of phosphodiesterase-4-inhibition
MA Schick, N Schlegel - International Journal of Molecular Sciences, 2022 - mdpi.com
… ), schizophrenia, allergies, autoimmune diseases, dementia and … signaling pathways are
included in pro- and anti-inflammatory cytokine release, antigen presentation, T-cell activation …
included in pro- and anti-inflammatory cytokine release, antigen presentation, T-cell activation …
[HTML][HTML] Cancers related to immunodeficiencies: update and perspectives
E Mortaz, P Tabarsi, D Mansouri, A Khosravi… - Frontiers in …, 2016 - frontiersin.org
… by mutations in the protein autoimmune regulator (AIRE), who … immunity and in the negative
regulation of inflammation (149). … X-linked inhibitor of apoptosis deficiency is mostly reported …
regulation of inflammation (149). … X-linked inhibitor of apoptosis deficiency is mostly reported …
[HTML][HTML] Dysregulation of lncRNAs in rheumatoid arthritis: biomarkers, pathogenesis and potential therapeutic targets
C Miao, L Bai, Y Yang, J Huang - Frontiers in pharmacology, 2021 - frontiersin.org
… , including cancers, mental diseases, autoimmune diseases and others. The abnormal …
control inhibited the apoptosis of RA FLSs and activated the PI3K/AKT signaling pathway. …
control inhibited the apoptosis of RA FLSs and activated the PI3K/AKT signaling pathway. …
Novel autoantibodies related to cell death and DNA repair pathways in systemic lupus erythematosus
H Luo, L Wang, D Bao, L Wang, H Zhao… - Genomics …, 2019 - academic.oup.com
… with various autoimmune processes, we performed molecular function and network …
autoimmune encephalomyelitis (EAE) by regulating M1 macrophage polarization [34]. Inhibition of …
autoimmune encephalomyelitis (EAE) by regulating M1 macrophage polarization [34]. Inhibition of …
Graves disease: latest understanding of pathogenesis and treatment options
G Lanzolla, M Marinò, F Menconi - Nature Reviews Endocrinology, 2024 - nature.com
… levels of TSHR-blocking antibodies or stimulating TRAbs 47 . … of T cell activation) might
play a role in autoimmunity … Although RAI leads to hypothyroidism and a requirement for …
play a role in autoimmunity … Although RAI leads to hypothyroidism and a requirement for …
B regulatory cells in patients with autoimmune diseases: Pathogenic significance and therapeutic potential
… autoimmune disease as they inhibit T helper 1 (Th1) and T helper 17 (Th17) cells. Although
there are several phenotypic B cell subsets with immunosuppressing functions… cell activation. …
there are several phenotypic B cell subsets with immunosuppressing functions… cell activation. …
New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B)
… the threshold for B cell activation and suppress autoimmune disease. In contrast, … autoimmune
B cells, via (i) opsonizing the target cells; and (ii) inhibiting FcγRIIB-negative regulation …
B cells, via (i) opsonizing the target cells; and (ii) inhibiting FcγRIIB-negative regulation …