… impairs lymphocyte activation and shapes their activation … with the B-cell antigen receptor
(BCR) via clonotypic antigen-binding … responsible for allergies and autoimmunity, by inducing …

… centers, while cTfr plays a negative role in both B cell activation and neuroinflammation. The
… apoptosis [62], which may involve the inhibition of mitochondrial function, ATP activity, and …

… (PV), an autoimmune bullous skin disorder associated with … resistant to experimental
autoimmune encephalomyelitis, … lineage that requires T cell antigen receptor (TCR) stimulation …

… Prophylactic steroids may mitigate the risks associated with RAI … autoimmunity have been
reviewed in the recent past (3). … following T-cell activation, causing IGF-IR down-regulation (82)…

… , Bregs, MSCs) with negative regulation in the treatment of … regulatory cells and chimeric
antigen receptor (CAR) Tregs. In … Bregs were impaired in autoimmune disorders, and adoptive …

… or excessive immune activation (eg, allergy, autoimmunity, inflammatory … inhibitory motifs.
Early studies of LAG3’s mechanism supported the idea that LAG3 inhibited T-cell activation …

… thyroid cancer and for enhancing RAI uptake into thyroid glands (… autoimmune thyroid
disease and in TSHR immunized rodents; stimulating, blocking, and so called “neutral” antibodies; …

… of leukocytes and dendritic cells. TREM-5 is upregulated in conditions like inflammation… cell
activation, or unusual dendritic cell function. Inhibition of TREM-5 with monoclonal antibodies …

… molecule required to facilitate the T cell activation [28]. MiR-… 6, a negative regulator of the
cell cycle progression. MiR-31 … of the inhibitory receptor Fc gamma RIIB and B-cell receptor (…

… and activation of IRG proteins (12). Our results thus suggest that Irgm1-disinhibited IRGs in
one or more interacting cell types may be the proximal cause of autoimmune pathogenesis. …