… random time delay, but the resulting process is non-Markovian, making it difficult to infer
cell-to-cell heterogeneity in reaction rates and time … one to describe signaling cascades with a …

… On one end of the spectrum, we have a deterministic random … On the other end, we have a
uniform random variable Y with … a cell through a multistep cascade leading to specific output …

… inherent random fluctuations in copy numbers over time. How cells ensure precision in the
timing … We formulate event timing as a first-passage time problem, where an event is triggered …

… of time that it takes for a subject to execute a decision. Specifically, we define RT as the time
… We randomized the order of each condition across sessions: in the first and third sessions, …

… Random phosphorylations provide large amplitudes of intermediate phosphorylations In
signaling cascades … Figure 7 shows representative time-courses of a random model with up to …

… cascades. By contrast, epidemics propagate more efficiently in networks with long-range
connections, such as random … A crucial factor in the real-time detection of cascades is the time …

… Repetitive spikes of cytoplasmic Ca 2+ also arise when ligand-activated GPCRs engage
the G12/13 signaling cascade as previously described for GPR55, a family A GPCR …

… Therefore, if a signal has to be transmitted reliably on very short time … shorter average crossing
time without an increase in its relative fluctuations. … Random timing in signaling cascades …

… a two-step genetic cascade, and showed that the signaling time of the full cascade can be …
, T 2 , and T y are thee independent random variables. To estimate the distribution of T TOT we …

… per time). However, the waiting time until the next reaction occurs is a random variable…
Chemical reaction kinetics dictate that the response times are exponentially distributed. …