MAVS expression in alveolar macrophages is essential for host resistance against Aspergillus fumigatus

X Wang, C Cunha, MS Grau, SJ Robertson… - The Journal of …, 2022 - journals.aai.org
… Using our murine model, we identify alveolar macrophages as a key … Rapid host
defense against Aspergillus fumigatus involves alveolar macrophages with a predominance

Mitochondrial reactive oxygen species enhance alveolar macrophage activity against Aspergillus fumigatus but are dispensable for host protection

N Shlezinger, TM Hohl - MSphere, 2021 - Am Soc Microbiol
… role in host defense against aspergillosis and induces … of phagocytic cells (8) and involves
the assembly and formation of a … result in a higher lung fungal burden or in more rapid disease …

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection

SC Kerr, GJ Fischer, M Sinha, O McCabe… - PLoS …, 2016 - journals.plos.org
fumigatus conidia to mucins and macrophages requires the fucose … host defense in the
lung has not been elucidated in this study. While we have described an alveolar macrophage

Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
… resist and survive against human host defenses and, further, … European countries confirm the
predominance of IPA over other … Alveolar macrophages (AMs) inside the alveolar lumen are …

Innate and adaptive immune response to chronic pulmonary infection of hyphae of Aspergillus fumigatus in a new murine model

F Wang, C Zhang, Y Jiang, C Kou… - Journal of Medical …, 2017 - microbiologyresearch.org
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a
predominance of alternatively activated phenotype. PLoS One 2011; 6:e15943 [View Article]…

Host Response to Pulmonary Fungal Infections: a Highlight on Cell-Driven Immunity to Cryptococcus Species and Aspergillus fumigatus

O Dutta, JA Masso-Silva, K Wang, A Rivera - Current pharmacology …, 2017 - Springer
… to the main cell types involved in the pulmonary … alveolar macrophages, monocyte-derived
“classically” and “alternatively” activated macrophages are also key mediators of host defense

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing

EE Rosowski, N Raffa, BP Knox, N Golenberg… - PLoS …, 2018 - journals.plos.org
… wild-type and macrophage-deficient zebrafish larvae, a fast-… in the absence of macrophages
requires Myd88 signaling, we … Killing of Aspergillus fumigatus by alveolar macrophages is …

Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death

A Shah, S Kannambath, S Herbst, A Rogers… - American journal of …, 2016 - atsjournals.org
… of Af, we hypothesized that VASP is involved in actin-dependent phagocytosis and lateral …
Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant …

Lung colonization by Aspergillus fumigatus is controlled by ZNF77

S Gago, NLD Overton, N Ben-Ghazzi… - Nature …, 2018 - nature.com
… In the healthy host, fungal spores are rapidly cleared from the … and E-cadherin) known to be
involved in tight junction and cell … Aspergillus species might explain the predominance of A. …

Aspergillus fumigatus and aspergillosis: From basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021 - ingentaconnect.com
Aspergillus section Fumigati includes 63 species and the … ) contribute to the innate host
defence in vivo and neutrophils exert a … are killed by local alveolar macrophages, and has been …