Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF

J Cheng, HL Yang, CJ Gu, YK Liu… - … journal of …, 2019 - spandidos-publications.com
Reactive oxygen species (ROS), including H2O2 and … angiogenic cytokines and growth
factors is regulated by hypoxia, while tumor angiogenesis and subsequent rapid tumor growth

Reactive oxygen species and cancer paradox: to promote or to suppress?

S Galadari, A Rahman, S Pallichankandy… - Free Radical Biology …, 2017 - Elsevier
… , effectively kill cancer cells and overcome drug resistance via enhancing … tumor promoting
(tumorigenesis, angiogenesis, invasion and metastasis, and chemoresistance) and the tumor

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
… ), and vascular endothelial growth factor (VEGF). At high concentrations, ROS can cause …
target to inhibit tumor growth via impeding inflammation, angiogenesis, and metastasis. To …

A mini-review of reactive oxygen species in urological cancer: correlation with NADPH oxidases, angiogenesis, and apoptosis

Y Miyata, T Matsuo, Y Sagara, K Ohba… - International journal of …, 2017 - mdpi.com
cancer cell model, tumor growth and angiogenesis were suppressed by the concomitant
impairment of endothelial … in combination therapy versus control and single treatments, and a …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
… The depletion of NRF2 has displayed decreased tumor growth by enhancing oxidative stress-…
the migration of endothelial cells to tumor mass to promote angiogenesis through several …

[HTML][HTML] Sustained oxidative stress instigates differentiation of cancer stem cells into tumor endothelial cells: Pentose phosphate pathway, reactive oxygen species and …

ZG Movahed, R Yarani, P Mohammadi… - Biomedicine & …, 2021 - Elsevier
Tumor angiogenesis plays a vital role in tumor growth and metastasis. It is proven that in
tumor vasculature, endothelial cells (ECs) originate from a … Vascular endothelial growth factor …

Reactive oxygen species bridge the gap between chronic inflammation and tumor development

W Yu, Y Tu, Z Long, J Liu, D Kong… - Oxidative medicine …, 2022 - Wiley Online Library
… In this study, we assess the potential role of reactive oxygen species (ROS) … TAMs also
facilitate tumor-cell growth and angiogenesis by generating … Vascular endothelial growth factor …

Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem‐Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway

Z Zhao, J Gao, C Li, X Xu, Y Hu… - Oxidative Medicine and …, 2020 - Wiley Online Library
… Because vascular endothelial cells are … angiogenic pattern, in which the endothelial cells
of HCC are derived from the transdifferentiation of CSCs and whether this process is regulated

Reactive oxygen species and cancer: A complex interaction

S Saikolappan, B Kumar, G Shishodia, S Koul, HK Koul - Cancer letters, 2019 - Elsevier
Vascular endothelial growth factor … Understanding the mechanisms of tumor development
and progression is … cell (TEC) migration through the upregulation of angiogenesis related …

The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance

MS Weng, JH Chang, WY Hung, YC Yang… - … & Clinical Cancer …, 2018 - Springer
… Roles of NADPH oxidase (NOX)-derived reactive oxygen species (ROS) in regulating
angiogenesis. Hypoxia induces vascular endothelial growth factor (VEGF) production from tumor