… As an endogenous agonist for MOR, endomorphin-2 (EM2) is of high affinity and high … [22,23]
or to keep the release of EM2 by genetic engineering approach [24]. In our study, we …

… sequences of EM2 limit the possibility of engineering through transgene methods. In the
present study, we bypassed these obstacles by engineering a complex of gene for EM2 and a …

… endomorphin-1 and endomorphin-2 are present in mammalian immune tissues. J … tolerance
to endomorphin-1 and endomorphin-2 given intraventricularly in the rat. Eur J Pharmacol …

… In the present study, the pharmacological activities of C-terminal esterified endomorphin-2
(EM-2) analogs 1–3 were characterized by in vitro metabolic stability and octanol/buffer …

… In this review is reported a brief collection of recently published modified endomorphins,
for which the potentiality as painkiller was clearly demonstrated in vitro and in vivo. Selected …

… Endomorphins are among the most active endogenous … a series of novel endomorphin
analogs with multiple site … the activity of synthesized endomorphin analogs toward opioid …

Previously, we have investigated three C-terminal esterified endomorphin-2 (EM-2) analogs
EM-2-Me, EM-2-Et and EM-2-Bu with methyl, ethyl and tert-butyl ester modifications, …

Novel endomorphin analogs CEMR‐1 and CEMR‐2 produce potent and long‐lasting
antinociception with a favorable side effect p Page 1 This article has been accepted for publication …

… Herein we present the expedient synthesis of endomorphin-1 analogues containing
stereoisomeric β 2 -homo-Freidinger lactam-like scaffolds ([Amo 2 ]EM), and we discuss opioid …

… the prototypical MOR-selective endomorphin-1 analog CYT-1010 and to compare what is
known about the clinical potential of MOR-selective endomorphins with traditional opioids for …