Transcriptional basis of mouse and human dendritic cell heterogeneity

CC Brown, H Gudjonson, Y Pritykin, D Deep… - Cell, 2019 - cell.com
Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell … the mean gene expression from the dendritic cell cluster in …

Human blood CD1c+ dendritic cells encompass CD5high and CD5low subsets that differ significantly in phenotype, gene expression, and functions

X Yin, H Yu, X Jin, J Li, H Guo, Q Shi, Z Yin… - The Journal of …, 2017 - journals.aai.org
Dendritic cells (DCs) are professional APCs that control the initiation, orientation, and
magnitude of immune responses (1–3). DCs exhibit heterogeneity with respect to surface marker …

Human dendritic cells express the complement receptor immunoglobulin which regulates T cell responses

U Munawara, K Perveen, AG Small, T Putty… - Frontiers in …, 2019 - frontiersin.org
… The receptor has been reported to be exclusively expressed in macrophages. We now … also
expressed in human monocyte-derived dendritic cells (MDDC), including on the cell surface, …

Human dendritic cells in cancer

E Kvedaraite, F Ginhoux - Science immunology, 2022 - science.org
… Here, we review both antitumor and tolerogenic DC responses in cancer and discuss … in
blood, and blood cDC1 showed impaired response to Toll-like receptor 3 (TLR3) agonist poly (I:…

Human dendritic cells: ontogeny and their subsets in health and disease

SG Solano-Gálvez, SM Tovar-Torres, MS Tron-Gómez… - Medical …, 2018 - mdpi.com
… as the orchestrating cells of the immune response. The purpose of … Both subtypes of cDCs
display unique gene expression … Because CD14 + DCs lack CC chemokine receptor 7 (CCR7)…

Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

Y Minoda, I Virshup, I Leal Rojas, O Haigh… - Frontiers in …, 2017 - frontiersin.org
… Changes in gene expression by hu mouse dendritic cells (DC) as a result stimulation with …
CD141 + DC were previously identified as being major producers of IFNα in response to poly I:…

CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion

L Heger, S Balk, JJ Lühr, GF Heidkamp… - Frontiers in …, 2018 - frontiersin.org
Dendritic cells (DCs) are potent antigen-presenting cells capable of inducing and regulating
adaptive immune responses (1). They continuously sample pathogenic and harmless …

Substrate stiffness influences phenotype and function of human antigen-presenting dendritic cells

SFB Mennens, M Bolomini-Vittori, J Weiden… - Scientific reports, 2017 - nature.com
… to different receptor recycling dynamics or global receptor expression, we prepared whole
… on mDC responsiveness to chemokines, we first determined the cell surface expression of …

Dendritic cells revisited

M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
cells in both humans and mice capable of producing large amounts of type I interferons in
response to viruses and some Toll-like receptorcells able to stimulate T cell responses; they …

Dendritic cells, T cells and their interaction in rheumatoid arthritis

P Wehr, H Purvis, SC Law… - Clinical & Experimental …, 2019 - academic.oup.com
cells which bridge innate and adaptive immune responses, … chemokines, including chemokine
(CC motif) ligand 3 (CCL3)… of T and B cell gene expression, were significantly associated …