Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology

F Jaisser, N Farman - Pharmacological reviews, 2016 - ASPET
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Focus on receptors for coronaviruses with special reference to angiotensin-converting enzyme 2 as a potential drug target-a perspective

T Magrone, M Magrone, E Jirillo - Endocrine, Metabolic & …, 2020 - ingentaconnect.com
… , thus implicating that ACE2 may represent the binding receptors for COVID-19. Furthermore, …
point of view, evidence has been provided that binding of S2 to the ACE2 receptor leads to …

[HTML][HTML] Endothelin receptor antagonists: status quo and future perspectives for targeted therapy

FC Enevoldsen, J Sahana, M Wehland… - … of clinical medicine, 2020 - mdpi.com
… Thus, endothelin receptor antagonists (ERAs) have been approved for the treatment of this
… its receptors implicates their involvement in a wide variety of physiological and pathological

[HTML][HTML] The emerging role of insulin receptor isoforms in thyroid cancer: clinical implications and new perspectives

V Vella, R Malaguarnera - International journal of molecular sciences, 2018 - mdpi.com
… with IGF-1R, giving rise to the formation of hybrids receptors (HR-A or HR-B). Other … -integrin
collagen receptor, discoidin domain receptor 1 (DDR1), and the receptor for the hepatocyte …

[HTML][HTML] Estrogen-receptor-low-positive breast cancer: Pathological and clinical perspectives

CP Malainou, N Stachika, AK Damianou… - Current …, 2023 - mdpi.com
… and shed light on the biological and clinical perspectives of ER-low BC. … receptor family and
are encoded by two different genes, ESR1 and ESR2 [7]. Similarly to other nuclear receptors

[HTML][HTML] Novel biomarkers in heart failure: new insight in pathophysiology and clinical perspective

LM Biasucci, A Maino, MC Grimaldi… - … of clinical medicine, 2021 - mdpi.com
… are receptors for the inflammatory cytokine interleukin (IL)-33 and they are explicated in two
forms: membrane-bound and soluble. They belong to the IL-1 cytokine receptor superfamily …

Platelet biology and functions: new concepts and clinical perspectives

PEJ van der Meijden, JWM Heemskerk - Nature Reviews Cardiology, 2019 - nature.com
… be enriched in certain receptors (for example, GPVI), but not in other receptors (for example,
the GPIb–V–IX complex). Larger platelets are likely to be enriched in internal membranes (…

Insights into pathology and pathogenesis of coronavirus disease 2019 from a histopathological and immunological perspective

S Iida, T Arashiro, T Suzuki - JMA journal, 2021 - jstage.jst.go.jp
… The main host receptor for SARS-CoV-2 is angiotensin-con… -CoV-2 binds to ACE2 via the
receptor-binding domain (RBD) in the … to form extensive pulmonary pathology, which eventually …

Alport syndrome: a comprehensive review on genetics, pathophysiology, histology, clinical and therapeutic perspectives

AL Pedrosa, L Bitencourt, RM Paranhos… - Current Medicinal …, 2021 - ingentaconnect.com
… system (RAS) (ACE/Ang II/AT1 receptor) and the downregulation of the alternative axis (ACE2/Ang(1-7)/Mas
receptor) are important factors for AS onset and progression to CKD or …

Collective invasion of cancer: Perspectives from pathology and development

X Wang, A Enomoto, N Asai, T Kato… - Pathology …, 2016 - Wiley Online Library
Clinical pathologists have long been aware that in many types of human malignant tumors, the
… These studies provide new perspectives on the mechanistic analogy between cancer and …