… Establishment of the normal asymmetric left–right axis during … genes (biallelic variants for
autosomal recessive genes) (1–3). … Randomization of left-right asymmetry and congenital heart …

… We found 52 different variants, 36 of which were not … caused by variants in different genes
encoding ciliary axoneme proteins. Most genes associated with PCD are autosomal recessive, …

… identified to follow the autosomal recessive mode of inheritance, with … The function of the
ZMYND10 protein is not fully understood … with randomization of left/right body asymmetry. The …

… recessive disorder characterized by motile cilia dysfunction. Clinical manifestations of PCD
include chronic upper and lower airway disease, left–right … -causing genes are not screened …

… , ciliary motility plays a crucial role in the formation of left/right … The mode of inheritance of
PCD is autosomal recessive, except for (1… SPEF2- and HYDIN-mutant cilia lack the central pair-…

… left right body axis determination [33]. There are two main perceptions by which initial body
asymmetry is … Primary ciliary dysfunction can cause defects in sensory and visceral organs, …

… There are limited randomized controlled trials in PCD patient populations… left-right asymmetry.
Curr Top Dev Biol. 2008;85:151-74. … cases caused by DNAH11 and HYDIN variants. (27) • …

… Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right
body asymmetry. Am J Hum Genet. 2012;91(4):672-84. …

… previously reported patients with primary ciliary dyskinesia with variants in HYDIN. … Recessive
HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body …

… of patients who might enter randomised controlled trials of … disease-causing mutations in
autosomal recessive PCD or … associated protein HYDIN, do not result in laterality defects. In …