… significance in colorectal carcinoma. These factors include: … of the immunohistochemical
aspects of tumor suppressor … Evidence of reciprocity of bcl-2 and p53 expression in human …

… activation of p53 by Ser15 phosphorylation transactivates Bax … of the genome, TP53 tumor
suppressor gene was found mutated in 85% of colorectal cancers [290] with 70% of the TP53 …

… in the tumor suppressor p53 are highly prevalent in cancers … a clear p53-dependent
regulation of BAX expression in … that a reciprocal regulatory relationship exists between the two …

… resveratrol boosted the acetylation of p53, the expression of p21, Bax, cytochrome C, … factor
p53, and thereby deactivates an important tumor suppressor protein in tumor cells (41, 42). …

… On the other hand, TAD2 disruption retains similar wild-type functions capable of inducing
p53 target genes p21, Bax, Noxa, and Puma as well as the ability to induce cell cycle arrest …

… relationship between p53 function and metabolic disorders. In addition, mutant p53 protein
does not only lose the tumor suppressor … and contributes to tumor development, involving …

… One report revealed a direct relation between oxidative stress and p53 mutation in CRC [36]…
ROS-mediated activation of BH3 interacting-domain death agonist (BID), Bax, caspases, …

… defined mass or volume) increases linearly with a reciprocal decrease in particle size. The
dose–… determinants of cell death are the tumor suppressor protein p53 and its target BAX [49]. …

… ), p53, deleted in colorectal carcinoma or activated mutations … The classical tumor suppressor
gene TP53 is one of the most … cell proliferation and increased Bax-dependent apoptosis by …

… To test this hypothesis, we performed reciprocal co-IP experiments with anti-p53 and anti-MDM2 …
, anti-proliferative gene (p21) and pro-apoptotic genes (Bax and cleaved caspase 3) …