… of p53 tumor suppressor function is lacking. Understanding the underpinnings of p53 tumor
suppressor function is of … BCL-2 family members or directly activate BAX and BAK to trigger …

… the critical tumor suppressor p53 and promotes survival [18]. In … -3β/Bax and diminished
Bcl-xL in other colon cancer cells … GSK-3β and Bax complex was further confirmed by reciprocal …

… patterns of the tumor suppressor p53 in cancer cells reflect … the impact of nuclear p53
accumulation and its activation on the BAX/… The distribution of reciprocal interatomic distances was …

… of p53 as well as reduced expression of the p53-dependent genes Cdkn1a, Bax and …
co-immunoprecipitated with endogenous p53 or overexpressed GFP-p53 in reciprocal IPs and that …

… -2 family of proteins and p53 tumor suppressor protein which is … However, the long isoform
of cFLIP, FLIP L , has reciprocal … trioxide through upregulation of p53 and its target gene Bax. …

… be constitutively activated in colorectal cancers and although it has … protein expression of
Bid, Bad, and Bax [87]. A further series … Other oncogenes/tumor suppressor genes known to be …

… against colorectal cancers (CRC); however, the primary mechanism by … p53 is a tumor
suppressor protein that regulates cell … of p21 and Bax, suggestive of a role in restoration of p53 …

… the existence of an intricate reciprocal interplay between Mst1 … Mst1 functions as a tumor
suppressor in CRC by regulating … the expression levels of caspase3, caspase9, and Bax but …

… Deleted in colorectal carcinoma … as the lethality of MDM2 deficiency can be rescued by the
loss of TP53 [21, … instability and frameshift mutations in BAX and transforming growth factor-…

… of a transcriptionally coordinated crosstalk between p53 and … and p53 pathways engage in
pervasive reciprocal crosstalk … of function between these critical tumor suppressor pathways…