Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the …

KK Griendling, RM Touyz, JL Zweier, S Dikalov… - Circulation …, 2016 - Am Heart Assoc
… , fluorescence detection in the presence of redox-sensitive probes, and either direct or spin
… in a stepwise manner to sulfinic acid and sulfonic acid (Figure 3). Sulfenic acid can be redox …

A global profile of reversible and irreversible cysteine redox post-translational modifications during myocardial ischemia/reperfusion injury and antioxidant intervention

AW Rookyard, J Paulech, S Thyssen… - Antioxidants & Redox …, 2021 - liebertpub.com
… known means of reduction (Cys-sulfinic and -sulfonic acid; Cys-SO 2 H… Redox-sensitive
cysteines (Cys) are important in the … O-linked GlcNAc modification of cardiac myofilament proteins…

Exploring Redox Biology in physiology and disease

A Koning - 2017 - research.rug.nl
modifications (including formation of sulfinic acid, sulfenic … regulation is achieved by interaction
with redox-sensitive … hence is a marker of risk for cardiovascular disease (95,138). The …

Post-translational S-nitrosylation of proteins in regulating cardiac oxidative stress

X Shi, H Qiu - Antioxidants, 2020 - mdpi.com
… thus more precisely targeting the redox-sensitive cysteine thiols and facilitating signal … acid
is not a selective reductant of SNOs, and MMTS can exhibit cross-reactivity with sulfenic acids

Activity-based sensing for site-specific proteomic analysis of cysteine oxidation

Y Shi, KS Carroll - Accounts of chemical research, 2019 - ACS Publications
… molecular technique to elucidate redox-regulated signaling pathways and offer new insights
redox-sensitive Cys149 exhibited an increase in the fraction of sulfenic acid modification in …

Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function

SI Bibli, J Hu, M Looso, A Weigert, C Ratiu, J Wittig… - Circulation, 2021 - Am Heart Assoc
… Despite the clear link to cardiovascular health, little is known about the physiological and …
Use was made of the fact that CSE expression and H 2 S n generation are regulated by …

[HTML][HTML] Redox regulation of gasotransmission in the vascular system: A focus on angiogenesis

RK Mistry, AC Brewer - Free Radical Biology and Medicine, 2017 - Elsevier
… processes within the cardiovascular system including … act to modify cysteine residues
on redox-sensitive proteins [… sulphenic acid (SOH), sulphinic acid (SO 2 H) and sulphonic …

[HTML][HTML] Redoxins as gatekeepers of the transcriptional oxidative stress response

BL Hopkins, CA Neumann - Redox Biology, 2019 - Elsevier
… , a TF can up- or down-regulate gene expression by stabilizing or blocking binding of RNA …
a reactive cysteine thiolate, sulfenic acid, sulfinic acid, and finally sulfonic acid. With the aid of …

Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

AEM Beedle, S Lynham, S Garcia-Manyes - Nature communications, 2016 - nature.com
… individual sulfenic acid embedded within the core of a single Ig domain of the titin protein.
Our results demonstrate that sulfenic acid … exposed to mechanical forces, such as cardiac titin. …

Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation

M Yang, J Chiu, C Scartelli, N Ponzar, S Patel… - Journal of Thrombosis …, 2023 - Elsevier
… act as a redox-sensitive switch that controls protein function. … we tested the hypothesis that
sulfenic acids are generated by … Circulating oxLDL is elevated in patients with coronary artery